Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats

March 2022 in “ Research Square (Research Square) ”

Bengi Çınar Kul, Nüket Bilgen, Merve BİŞKİN, Mustafa Yenal Akkurt, Özge Şebnem Çıldır, Özge Özmen, Oğuz Kul

hair follicle development gene expression Angora goats mohair secondary hair follicles telogen phase anagen phase HOXC13 TGFBR2 FGF-5 BMP-2 KAP9.2 hair growth resting phase growth phase

TLDR Seasonal changes affect gene activity linked to hair growth in Angora goats, influencing mohair quality.

The study investigated the impact of seasonal changes on gene expression related to hair follicle development in Angora goats, focusing on the mohair produced by secondary hair follicles. Skin biopsies from 20 goats were analyzed during the telogen (resting) and anagen (growth) phases in February and June, respectively. The results showed that the gene HOXC13 had high expression levels during the anagen phase but was undetectable during telogen. Other genes such as TGFBR2, FGF-5, and BMP-2 were significantly upregulated during anagen, while KAP9.2 expression remained constant between phases. This study is the first to examine hair follicle-related genes in Angora goats and suggests that the overexpression of HOXC13 may contribute to the shiny and silky quality of mohair, with variations potentially due to geographic or breed differences.

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