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research Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes

79 citations , January 2002 in “Nucleic Acids Research”

This study found that BMP-2 activates Dlx3 gene transcription in murine keratinocytes by binding with Smad1/Smad4, suggesting a mechanism for BMP signaling's role in skin and hair follicle regulation.

research Binding Interactions of Keratin-Based Hair Fiber Extract to Gold, Keratin, and BMP-2

22 citations , August 2015 in “PloS one”

This study found that the binding and release of BMP-2 from kerateine biomaterials are significantly influenced by pH and salt concentration, highlighting the potential for developing improved bone repair systems.

research BMP2 and BMP7 play antagonistic roles in feather induction

88 citations , July 2008 in “Development”

This study shows that BMP2 and BMP7 play complex, necessary roles in feather development by regulating dermal condensation formation, with BMP7 acting early as a chemoattractant and BMP2 halting cell migration.

research The periosteal requirement and temporal dynamics of BMP2‐induced middle phalanx regeneration in the adult mouse

31 citations , June 2017 in “Regeneration”

This study found that applying BMP2 stimulated limited regeneration of the amputated P2 bone in mice, but only when applied during a specific "regeneration window" after injury.

research BMP2-mediated PTEN enhancement promotes differentiation of hair follicle stem cells by inducing autophagy

24 citations , September 2019 in “Experimental cell research”

This study found that BMP2 increased PTEN expression and induced autophagy, promoting hair follicle stem cell differentiation in both in vitro models and a mouse wound model.

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Community Join

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community Before and after of 20 months of fin and min

in Progress Pictures 125 upvotes 7 months ago

The user experienced worsening hair thinning despite using finasteride, minoxidil, and ketoconazole shampoo, and switched to dutasteride five months ago. They are considering adding tretinoin and microneedling to their routine for better results.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community GT20029 and PP405 the new fin and min that we been waiting for ?

36 upvotes 1 year ago

PP405 and GT20029 are new hair loss treatments with different mechanisms from traditional options like Minoxidil and Finasteride. PP405 targets hair follicle stem cells to reactivate growth, while GT20029 works as an androgen receptor deleter, both requiring ongoing use for effectiveness.

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learn PTD-DBM

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