Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats
November 2022
in “
Research Square (Research Square)
”
hair follicle development BMP-2 FGF-5 HOXC13 KAP9.2 TGFBR2 telogen phase anagen phase gene expression Angora goats mohair hair growth bone morphogenetic protein 2 fibroblast growth factor 5 homeobox C13 keratin-associated protein 9.2 transforming growth factor beta receptor 2 resting phase growth phase
TLDR Seasonal changes affect hair growth genes in Angora goats, possibly influencing mohair quality.
The study investigated the impact of seasonal changes on gene expression related to hair follicle development in Angora goats, focusing on genes BMP-2, FGF-5, HOXC13, KAP9.2, and TGFBR2. Skin biopsies from 20 goats were analyzed during the telogen and anagen phases of hair growth, in February and June respectively. The results showed that HOXC13 had high expression levels during the anagen phase but was undetectable during telogen. TGFBR2, FGF-5, and BMP-2 were significantly upregulated in the anagen phase, while KAP9.2 expression remained constant between phases. This study, the first of its kind on hair follicle-related genes in Angora goats, suggests that the overexpression of HOXC13 may contribute to the shiny and silky quality of mohair and indicates that gene expression varies with seasonal changes and possibly differs by geographic zones or breeds.
