Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats

November 2022 in “ Research Square (Research Square) ”

Bengi Çınar Kul, Nüket Bilgen, Merve BİŞKİN, Mustafa Yenal Akkurt, Özge Şebnem Çıldır, Özge Özmen, Oğuz Kul

hair follicle development BMP-2 FGF-5 HOXC13 KAP9.2 TGFBR2 telogen phase anagen phase gene expression Angora goats mohair hair growth bone morphogenetic protein 2 fibroblast growth factor 5 homeobox C13 keratin-associated protein 9.2 transforming growth factor beta receptor 2 resting phase growth phase

Studysummary This study found that HOXC13 gene expression was significantly higher during the anagen phase in Angora goats, potentially contributing to the mohair's shiny and silky nature. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the impact of seasonal changes on gene expression related to hair follicle development in Angora goats, focusing on genes BMP-2, FGF-5, HOXC13, KAP9.2, and TGFBR2. Skin biopsies from 20 goats were analyzed during the telogen and anagen phases of hair growth, in February and June respectively. The results showed that HOXC13 had high expression levels during the anagen phase but was undetectable during telogen. TGFBR2, FGF-5, and BMP-2 were significantly upregulated in the anagen phase, while KAP9.2 expression remained constant between phases. This study, the first of its kind on hair follicle-related genes in Angora goats, suggests that the overexpression of HOXC13 may contribute to the shiny and silky quality of mohair and indicates that gene expression varies with seasonal changes and possibly differs by geographic zones or breeds.

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