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Glossary Proliferating Cell Nuclear Antigen

protein marker for cell division and DNA repair

Proliferating Cell Nuclear Antigen (PCNA) is a protein that acts as a marker for cell proliferation, meaning it helps identify cells that are actively dividing. It plays a crucial role in DNA replication and repair, making it important for both normal cell growth and the response to DNA damage.

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research An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution

170 citations , November 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that in the absence of hair follicles, cutaneous wounds in mice showed delayed reepithelialization but eventually achieved normal wound closure after expanding the activated epidermis region.

research Maintenance of high proliferation and multipotent potential of human hair follicle-derived mesenchymal stem cells by growth factors

56 citations , February 2013 in “International Journal of Molecular Medicine”

This study found that human hair follicle-derived mesenchymal stem cells maintained their proliferation and differentiation potential when cultured with acidic fibroblast growth factor, basic fibroblast growth factor, or epidermal growth factor.

Oral Administration of Low-Dose Bisphenol A Promotes Proliferation of Ventral Prostate and Upregulates Prostaglandin D2 Synthase Expression in Adult Rats

research Oral administration of low-dose bisphenol A promotes proliferation of ventral prostate and upregulates prostaglandin D₂ synthase expression in adult rats

14 citations , June 2015 in “Toxicology and Industrial Health”

This study found that low doses of bisphenol A may increase proliferation of the ventral prostate in adult rats by altering the estrogen to androgen ratio and gene expression.

research Hominis Placenta facilitates hair re-growth by upregulating cellular proliferation and expression of fibroblast growth factor-7

13 citations , July 2016 in “BMC Complementary and Alternative Medicine”

In this study, topical application of Hominis Placenta significantly promoted hair regrowth and increased hair density in C57BL/6 mice, suggesting its potential as a treatment for alopecia.

research Effect of Flightless I Expression on Epidermal Stem Cell Niche During Wound Repair

10 citations , July 2019 in “Advances in Wound Care”

This study suggests that Flightless I may inhibit the activation of epidermal stem cells during wound repair by disrupting Wnt/β-catenin signaling, potentially delaying wound reepithelialization.

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community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

121 upvotes 2 years ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Lion Mane Part 2: Microneedling with Topicals, beneficial compounds, maybe?

1 upvotes 2 years ago

The conversation discusses microneedling techniques and the use of Minoxidil, copper peptides, EGF, FGF, ceramides, and hydration serums to enhance hair growth. It explores optimizing scalp conditions and the potential benefits of various compounds in conjunction with microneedling.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

14 upvotes 2 years ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

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