The Success of Thread-Embedding Therapy in Generating Hair Regrowth in Mice Points to Its Possible Effect in Humans

December 2015 in “ Journal of Pharmacopuncture ”

Hyun Jong Shin, Dong Hoon Lee, Kang Kwon, Hyung-Sik Seo, Hyein Jeong, Ji-Yeon Lee, Ki-Tae Ha, Chang-Hyun Lee, Yong-Suk Jang, Byung-Wook Lee, Byung Joo Kim, Minyoung Jung

thread-embedding therapy hair regrowth anagen phase hair follicles cellular proliferation bromodeoxyuridine proliferating cell nuclear antigen fibroblast growth factors FGF-7 FGF-5 minoxidil alopecia TET hair growth BrdU PCNA FGF

Studysummary In this study, thread-embedding therapy enhanced hair regrowth in C57BL/6 mice by regulating growth factors associated with hair follicle anagen development and promoting cellular proliferation in hair follicles. Our plain-language summary of this paper — not a Tressless recommendation.

The study from December 31, 2015, demonstrated that thread-embedding therapy (TET) significantly promoted hair regrowth in C57BL/6 mice by inducing the anagen phase of hair follicles and increasing cellular proliferation, as evidenced by the elevated expression of bromodeoxyuridine (BrdU) and proliferating cell nuclear antigen (PCNA). TET also regulated the expression of fibroblast growth factors FGF-7 and FGF-5, which are key in hair follicle development and the hair growth cycle. The effects of TET were comparable to those observed with minoxidil treatment, suggesting that TET could be a potential alternative therapy for alopecia. The study was funded by the Research Fund Program of the Research Institute for Basic Sciences at Pusan National University, Korea.

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