Effects of Lespedeza Cuneata Aqueous Extract on Testosterone-Induced Prostatic Hyperplasia

January 2019 in “ Pharmaceutical biology ”

Bong Kyun Park, Chang Won Kim, Jeong Eun Kwon, Manorma Negi, Yong Tae Koo, Sang Hun Lee, Dong Hyun Baek, Young Noh, Se Chan Kang

Lespedeza cuneata testosterone-induced prostatic hyperplasia dihydrotestosterone DHT 5α-reductase inflammatory cytokines proliferating cell nuclear antigen PCNA fibroblast growth factor-2 FGF-2 androgen receptor AR prostate-specific antigen PSA finasteride 5-alpha-reductase Propecia

Studysummary This study found that Lespedeza cuneata aqueous extract reduced serum dihydrotestosterone levels and 5α-reductase mRNA expression in testosterone-induced prostatic hyperplasia in rats, suggesting potential as a treatment for prostatic hyperplasia.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study investigated the effects of Lespedeza cuneata aqueous extract (LCW) on testosterone-induced prostatic hyperplasia (TPH) in rats and BPH-1 cells. LCW significantly reduced prostate weight, serum dihydrotestosterone (DHT) levels, and 5α-reductase expression. It also inhibited inflammatory cytokines and reduced mRNA expression of proliferating cell nuclear antigen (PCNA) and fibroblast growth factor-2 (FGF-2). In BPH-1 cells, LCW decreased androgen receptor (AR) and prostate-specific antigen (PSA) levels. These findings suggested that LCW could be a potential therapeutic agent for treating prostatic hyperplasia, comparable to finasteride, and could be considered as a functional food supplement. Further research was needed to identify the active compounds and molecular mechanisms responsible for its efficacy.

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