Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia

    December 2016 in “ Sexual Medicine ”
    Sabina Cauci, Giovanni Chiriaco, Erika Cecchin, Giuseppe Toffoli, Serena Xodo, Giuseppe Stinco, Carlo Trombetta
    Image of study
    TLDR Finasteride side effects in young men may be linked to specific gene variations.
    This study investigated the relationship between the length of two trinucleotide repeats in the androgen receptor (AR) gene and symptoms reported by young men who experienced long-lasting adverse effects after using finasteride against androgenic alopecia. The study found that the (CAG)n and (GGN)n polymorphisms were involved in specific symptoms, and for other symptoms, only one of the two polymorphisms was involved. The study suggests that genetic implications may play a role in the symptoms experienced by patients with post-finasteride syndrome, but more research is needed to understand the pathophysiological pathways leading to the onset and persistence of adverse effects in former finasteride users.
    Discuss this study in the Community →

    Research cited in this study

    16 / 16 results

    Related Community Posts Join

    6 / 1000+ results

      community 3 months 5g Min only before/after, 26 y/o

      in Is this regrowth?  454 upvotes 1 week ago
      The user experienced significant hair regrowth after three months of using 5 mg oral minoxidil nightly and plans to add finasteride to maintain progress. Many recommend combining minoxidil with finasteride or dutasteride to prevent future hair loss.

      community Found this meme on a forum……..

      in Satire  150 upvotes 11 months ago
      The conversation is about a meme related to hair loss that influenced someone to start taking finasteride. Another person agrees that the meme accurately represents the situation.

      community Binding affinity of pyrilutamide!

      in Update  167 upvotes 2 years ago
      Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

      community Hair loss causes are still a myth.

      in Chat  16 upvotes 3 years ago
      The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.

      community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

      in Research/Science  122 upvotes 1 year ago
      The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

    Related Research

    1 / 1 results