Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia

    December 2016 in “ Sexual Medicine ”
    Sabina Cauci, Giovanni Chiriaco, Erika Cecchin, Giuseppe Toffoli, Serena Xodo, Giuseppe Stinco, Carlo Trombetta
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    TLDR Finasteride side effects in young men may be linked to specific gene variations.
    This study investigated the relationship between the length of two trinucleotide repeats in the androgen receptor (AR) gene and symptoms reported by young men who experienced long-lasting adverse effects after using finasteride against androgenic alopecia. The study found that the (CAG)n and (GGN)n polymorphisms were involved in specific symptoms, and for other symptoms, only one of the two polymorphisms was involved. The study suggests that genetic implications may play a role in the symptoms experienced by patients with post-finasteride syndrome, but more research is needed to understand the pathophysiological pathways leading to the onset and persistence of adverse effects in former finasteride users.
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