Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia

    December 2016 in “ Sexual Medicine ”
    Sabina Cauci, Giovanni Chiriaco, Erika Cecchin … Carlo Trombetta
    Studysummary This study identified differences in adverse symptoms among patients with post-finasteride syndrome based on short and long androgen receptor gene polymorphisms.
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    Research cited in this study 18

    1. Effect of 5α-Reductase Inhibitors on Sexual Function: A Meta-Analysis and Systematic Review of Randomized Controlled Trials The Journal of Sexual Medicine · 2016
    2. An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia International Journal of Andrology · 2016
    3. Adverse Effects of 5α-Reductase Inhibitors: What Do We Know, Don't Know, and Need to Know? Reviews in Endocrine and Metabolic Disorders · 2015
    4. Interventions for Hirsutism (Excluding Laser and Photoepilation Therapy Alone) Cochrane library · 2015
    5. Safety Concerns Regarding 5α Reductase Inhibitors for the Treatment of Androgenetic Alopecia Current Opinion in Endocrinology, Diabetes and Obesity · 2015
    6. Androgens Induce Sebaceous Differentiation in Sebocyte Cells Expressing a Stable Functional Androgen Receptor Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 2015
    7. Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-Analysis PubMed · 2015
    8. A Pharmacogenetic Survey of Androgen Receptor (CAG)N and (GGN)N Polymorphisms in Patients Experiencing Long-Term Side Effects After Finasteride Discontinuation International Journal of Biological Markers · 2014
    9. Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia PLOS ONE · 2014
    10. Organic Causes of Erectile Dysfunction in Men Under 40 Urologia Internationalis · 2013
    11. The Role of Androgen and Androgen Receptor in Skin-Related Disorders Archives of Dermatological Research · 2012
    12. Androgen Receptor Gene Polymorphisms and Risk for Androgenetic Alopecia: A Meta-Analysis Clinical and Experimental Dermatology · 2011
    13. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    14. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    15. Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia Archives of Dermatology · 2010
    16. Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride Hormone Molecular Biology and Clinical Investigation · 2010
    17. Significance of the Polyglutamine Tract Polymorphism in the Androgen Receptor Urology · 2001
    18. Predominant Expression of 5 Alpha-Reductase Type 1 in Pubic Skin from Normal Subjects and Hirsute Patients ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 1996

    Related research 1

    1. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992