Mir-370-3p Inhibited the Proliferation of Sheep Dermal Papilla Cells by Inhibiting the Expression of SMAD4

This study explores the role of miR-370-3p in sheep dermal papilla cells (DPCs) and its effect on hair follicle development by targeting the SMAD4 gene. Conducted on six sheep, the research found that miR-370-3p inhibits DPC proliferation by downregulating SMAD4 expression, which is crucial for hair growth. Overexpression of miR-370-3p leads to reduced cell proliferation and increased apoptosis, while SMAD4 overexpression has the opposite effect. The study also highlights miR-370-3p's influence on the Wnt/β-catenin signaling pathway and its potential as a target for modulating hair growth cycles.