MiR-23b and miR-133 Co-Target TGFβ2/NOTCH1 in Sheep Dermal Fibroblasts, Affecting Hair Follicle Development

The study explores the roles of miR-23b and miR-133 in sheep dermal fibroblasts and their influence on hair follicle development by targeting TGFβ2 and NOTCH1 genes. These microRNAs are found to inhibit cell proliferation and migration while promoting apoptosis, affecting hair follicle morphogenesis. The research involved various analyses, including dual-luciferase reporter assays and Western blotting, with a sample size of 3 for most experiments. The findings highlight the significant regulatory roles of miR-23b and miR-133 in hair follicle development, offering insights into potential genetic mechanisms for improving wool quality in superfine wool sheep.