MiR-23b and miR-133 Co-Target TGFβ2/NOTCH1 in Sheep Dermal Fibroblasts, Affecting Hair Follicle Development

    March 2024 in “ Cells ”
    Junmin He, Wei Chen, Xixia Huang, Guoping Zhang, Jingyi Mao, Xue Li, Cunming Yang, Wenjing Zhang, Kechuan Tian, Guifen Liu
    Studysummary This study found that the microRNAs oar-miR-23b and oar-miR-133 inhibit the proliferation and migration of sheep dermal fibroblasts, impacting the development of hair follicles in superfine wool sheep by targeting the genes TGFβ2 and NOTCH1. Our plain-language summary of this paper — not a Tressless recommendation.
    The study explores the roles of miR-23b and miR-133 in sheep dermal fibroblasts and their influence on hair follicle development by targeting TGFβ2 and NOTCH1 genes. These microRNAs are found to inhibit cell proliferation and migration while promoting apoptosis, affecting hair follicle morphogenesis. The research involved various analyses, including dual-luciferase reporter assays and Western blotting, with a sample size of 3 for most experiments. The findings highlight the significant regulatory roles of miR-23b and miR-133 in hair follicle development, offering insights into potential genetic mechanisms for improving wool quality in superfine wool sheep.
    Discuss this study in the Community →

    Research cited in this study

    26 / 26 results