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research Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair

86 citations , April 2016 in “Nature Communications”

This study suggests that Notch1 acts as a key signal in skin epithelium, promoting immune cell recruitment and aiding in normal skin repair after damage.

Adult Epidermal Notch Activity Induces Dermal Accumulation of T Cells and Neural Crest Derivatives Through Upregulation of Jagged 1

research Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1

34 citations , November 2010 in “Development”

In this study, epidermal Notch activation increased jagged 1 expression, leading to skin changes like thickening and blistering, with these effects inhibited when jagged 1 was absent.

Notch1 Signaling Regulates Wound Healing by Changing the Characteristics of Epidermal Stem Cells

research Notch1 Signaling Regulates Wound Healing via Changing the Characteristics of Epidermal Stem Cells

6 citations , January 2016 in “Journal of Stem Cell Research & Therapy”

This study found that suppressing Jagged1 in epidermal stem cells disrupted Notch signaling and resulted in poor-quality wound healing, suggesting a potential therapeutic target for improving wound repair.

research MiR-23b and miR-133 Cotarget TGFβ2/NOTCH1 in Sheep Dermal Fibroblasts, Affecting Hair Follicle Development

4 citations , March 2024 in “Cells”

This study found that the microRNAs oar-miR-23b and oar-miR-133 inhibit the proliferation and migration of sheep dermal fibroblasts, impacting the development of hair follicles in superfine wool sheep by targeting the genes TGFβ2 and NOTCH1.

research 199 Impairment of notch 1 signaling is a common defect in lesions from patients with hidradenitis suppurativa

2 citations , September 2017 in “Journal of Investigative Dermatology”

This study found that notch1 signaling is severely impaired in hidradenitis suppurativa patients with or without NCSTN or other gamma-secretase gene mutations, highlighting a canonical defect at the lesional tissue level.

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community Finasteride only (1mg) for 5 months

in Progress Pictures 139 upvotes 6 months ago

The user has been using 1mg of finasteride daily for 5 months, noticing hair regrowth and thickening without significant side effects. They have not used minoxidil and plan to continue with finasteride before considering additional treatments.

community 1 year Monthly Progress (Top Minox, Oral Fin, Vitamin D, Dermastamp)

50 upvotes 1 month ago

The user shared progress pictures after one year of using topical Minoxidil, oral Finasteride, Vitamin D, and dermastamping for hair loss. Many suggest continuing treatment, considering a hair transplant, or switching to dutasteride for better results.

community 1 year of 2-deoxy-D-ribose, what do you guys think?

91 upvotes 2 months ago

The conversation discusses using 2-deoxy-D-ribose for hair loss treatment, with OP sharing positive results after a year of use. OP applied a simple formulation twice daily, without using finasteride or minoxidil.

community 4600 FUT Hair Transplant 16 month post second surgery progress

in Transplants 3725 upvotes 1 year ago

The user had two FUT hair transplants with 4,600 grafts for increased density, costing about $11,000 each, and has been using oral minoxidil and finasteride for over five years without side effects. The results are natural-looking with no visible scarring, and the user finds the procedure valuable despite the cost.

community 14 months - 1mg fin & 5% topical minoxidil results

in Progress Pictures 452 upvotes 4 months ago

Significant hair regrowth was achieved using 1mg finasteride and 5% topical minoxidil over 14 months, with only initial shedding and mild scalp irritation as side effects. Consistency and early treatment are recommended for optimal results.

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