TLDR Blocking miR-27a increases sheep hair follicle stem cell growth and decreases cell death, which could help improve wool quality and treat hair loss.
The study "miR-27a Targeting PIK3R3 Regulates the Proliferation and Apoptosis of Sheep Hair Follicle Stem Cells" found that miR-27a, a type of microRNA, plays a significant role in the proliferation and apoptosis of hair follicle stem cells (HFSCs) in sheep. This is achieved by miR-27a targeting and downregulating the PIK3R3 gene, which subsequently reduces the activity of the AKT/MTOR pathway, leading to decreased HFSC proliferation and increased apoptosis. Conversely, inhibiting miR-27a led to increased PIK3R3, AKT, and MTOR expression, enhancing HFSC proliferation and reducing apoptosis. These findings suggest that miR-27a could be a crucial regulator of sheep HFSC proliferation and apoptosis, potentially providing insights for improving wool quality and developing new treatments for hair loss conditions.
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August 2017 in “PloS one” Key genes linked to hair growth and cancer were identified in hairless mice.
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October 2013 in “Yichuan” miRNAs are key in skin and hair growth and maintenance.
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November 2006 in “Experimental Dermatology” The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.
September 2023 in “Frontiers in medicine” The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.
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October 2021 in “Research Square (Research Square)” Melatonin affects certain genes and pathways involved in cashmere goat hair growth.
June 2021 in “Research Square (Research Square)” Melatonin can increase cashmere yield by altering gene expression and restarting the growth cycle early.
