Skin-Inspired Phototherapeutic Cryogel Ameliorates Infected Wound Healing by Orchestrating Mechanotransduction and Immunomodulation
November 2025
in “
Bioactive Materials
”
cryogel DNA/gelatin methacrylate metal-organic framework plasmonic Ti3C2Tx MXene photosensitizer MRSA wound healing angiogenesis epidermis formation granulation hair follicle growth anti-inflammatory effects methacrylate Ti3C2Tx staph infection new blood vessel formation skin layer formation tissue growth hair growth reduce inflammation
TLDR The cryogel effectively heals infected wounds and promotes tissue regeneration without scarring.
The study introduces a novel DNA-based cryogel incorporating MXene and Zn2+ ions, designed to combat MRSA infections and promote chronic wound healing. The cryogel uses near-infrared (NIR) triggered mild phototherapy to achieve strong antibacterial effects, enhance tissue regeneration, and promote scarless healing and hair growth. It facilitates these processes by enhancing keratinocyte activity, angiogenesis, and macrophage polarization towards an anti-inflammatory phenotype. The cryogel's structure supports tissue engineering applications, with effective heat generation for antimicrobial action and Zn2+ release enhanced by NIR irradiation. The study highlights the cryogel's potential for safe and effective wound healing, particularly in infected skin wounds, although it does not specify the number of participants involved.
