Glycosaminoglycans’ Ability to Promote Wound Healing: From Native Living Macromolecules to Artificial Biomaterials

    December 2023 in “ Advanced science ”
    Peng Yang, Yifei Lü, Wenyu Gou, Ya‐Zhen Qin, Jianglin Tan, Gaoxing Luo, Qing Zhang
    TLDR Glycosaminoglycans help heal wounds but aren't yet ready for clinical use.
    Glycosaminoglycans (GAGs) are crucial for wound healing due to their roles in maintaining tissue biomechanical properties, modulating inflammation, and promoting cell proliferation and angiogenesis. GAG-based biomaterials, such as hydrogels, microspheres, and nanoparticles, offer promising solutions for wound treatment by providing a moist environment, isolating bacteria, and enhancing tissue regeneration. Despite their potential, commercializing these biomaterials remains challenging due to the complexity of mimicking natural GAGs. Further research is needed to develop effective clinical applications by exploring the structure and properties of diverse natural GAGs.
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