Glycosaminoglycans’ Ability to Promote Wound Healing: From Native Living Macromolecules to Artificial Biomaterials

December 2023 in “ Advanced science ”

Peng Yang, Yifei Lü, Wenyu Gou, Ya‐Zhen Qin, Jianglin Tan, Gaoxing Luo, Qing Zhang

glycosaminoglycans GAGs wound healing tissue biomechanical properties inflammation modulation cell proliferation angiogenesis GAG-based biomaterials hydrogels microspheres nanoparticles tissue regeneration inflammation cell growth blood vessel formation biomaterials tissue repair

Studysummary This review discusses the roles and mechanisms of glycosaminoglycans in wound healing and presents challenges and potential applications for GAG-based biomaterials without reporting new experimental results. Our plain-language summary of this paper — not a Tressless recommendation.

Glycosaminoglycans (GAGs) are crucial for wound healing due to their roles in maintaining tissue biomechanical properties, modulating inflammation, and promoting cell proliferation and angiogenesis. GAG-based biomaterials, such as hydrogels, microspheres, and nanoparticles, offer promising solutions for wound treatment by providing a moist environment, isolating bacteria, and enhancing tissue regeneration. Despite their potential, commercializing these biomaterials remains challenging due to the complexity of mimicking natural GAGs. Further research is needed to develop effective clinical applications by exploring the structure and properties of diverse natural GAGs.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Glycosaminoglycans’ Ability to Promote Wound Healing: From Native Living Macromolecules to Artificial Biomaterials

2 citations , December 2023 in “Advanced science”

This review discusses the roles and mechanisms of glycosaminoglycans in wound healing and presents challenges and potential applications for GAG-based biomaterials without reporting new experimental results.

Self-Healing and Shape-Adaptive Nanocomposite Hydrogels With Anti-Inflammatory, Antioxidant, Antibacterial Activities and Hemostasis for Real-Time Visual Regeneration of Diabetic Wounds

research Self-Healing and Shape-Adaptive Nanocomposite Hydrogels With Anti-Inflammatory, Antioxidant, Antibacterial Activities and Hemostasis for Real-Time Visual Regeneration of Diabetic Wounds

4 citations , May 2023 in “Composites Part B: Engineering”

In this study, a novel nanocomposite hydrogel was developed for diabetic wound care, demonstrating superior tissue adhesion, antibacterial properties, and healing capabilities in vivo and in vitro, while also allowing real-time pH monitoring to aid clinical management.

research Crafting Polymeric and Peptidic Hydrogels for Improved Wound Healing

68 citations , March 2019 in “Advanced Healthcare Materials”

This review assesses the benefits and limitations of various supramolecular hydrogels, including polymeric and peptide-based types, for wound healing, but reports no new clinical results.

research Pericytes in Wound Healing: Friend or Foe?

23 citations , June 2015 in “Experimental Dermatology”

In this study, Mills et al. reported that inoculating human pericytes into murine wounds delayed dermal repair, revealing a need for better understanding of pericyte activity during skin injury repair.