TLDR Glycosaminoglycans help heal wounds but aren't yet ready for clinical use.
Glycosaminoglycans (GAGs) are crucial for wound healing due to their roles in maintaining tissue biomechanical properties, modulating inflammation, and promoting cell proliferation and angiogenesis. GAG-based biomaterials, such as hydrogels, microspheres, and nanoparticles, offer promising solutions for wound treatment by providing a moist environment, isolating bacteria, and enhancing tissue regeneration. Despite their potential, commercializing these biomaterials remains challenging due to the complexity of mimicking natural GAGs. Further research is needed to develop effective clinical applications by exploring the structure and properties of diverse natural GAGs.
2 citations,
December 2023 in “Advanced science” Glycosaminoglycans help heal wounds but aren't yet ready for clinical use.
4 citations,
May 2023 in “Composites Part B: Engineering” The nanocomposite hydrogels can repair themselves, change shape, reduce inflammation, protect against oxidation, kill bacteria, stop bleeding, and help heal diabetic wounds while allowing for wound monitoring.
68 citations,
March 2019 in “Advanced Healthcare Materials” Advanced hydrogel systems with therapeutic agents could greatly improve acute and chronic wound treatment.
43 citations,
July 2019 in “Stem Cells International” Advancements in creating skin grafts with biomaterials and stem cells are promising, but more research is needed for clinical application.
1160 citations,
November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
January 2023 in “Biomaterials Science” Certain genes are more active during wound healing in axolotl and Acomys, which could help develop materials that improve human wound healing and regeneration.
65 citations,
March 2018 in “Journal of Dermatological Science” Skin problems can be caused or worsened by physical forces and pressure on the skin.
29 citations,
September 2020 in “International Journal of Molecular Sciences” The document concludes that freeze-dried platelet-rich plasma shows promise for medical use but requires standardization and further research.
