Freeze-Drying of Platelet-Rich Plasma: The Quest for Standardization

The document reviews the potential and challenges of freeze-dried platelet-rich plasma (FD-PRP) in medical applications, emphasizing the need for standardization. It covers the use of FD-PRP in skin research, wound healing, musculoskeletal conditions, dentistry, and alopecia treatment. The review indicates that FD-PRP maintains biological activity and can be combined with biomaterials for advanced wound dressings and controlled growth factor release. It also compares favorably to fresh PRP in various applications, including bone regeneration and musculoskeletal research. The document suggests that FD-PRP could become a standardized off-the-shelf product, but notes the need for further research, optimization of freeze-drying procedures, and regulatory compliance. Safety concerns are addressed through donor testing and sterilization methods. The review was supported by the Basque Industry Department and the Basque Health Department, with no conflicts of interest declared by the authors.