Effect of Freeze-Drying Process of Collagen-Activated Platelet-Rich Plasma on Transforming Growth Factor-β1 Level

January 2020 in “ Majalah Kedokteran Gigi Indonesia ”

Kwartarini Murdiastuti, Fitri Yuniawati, Dahlia Herawati, Nunuk Purwanti, Dyah Ayu Mira Oktarina

platelet-rich plasma collagen-activated platelet-rich plasma transforming growth factor-β1 TGF-β1 PRP collagen-activated PRP

TLDR Freeze-drying collagen-activated PRP increases TGF-β1 levels, enhancing tissue regeneration potential.

The study investigated the effect of freeze-drying collagen-activated platelet-rich plasma (PRP+C) on transforming growth factor-β1 (TGF-β1) levels, which are crucial for bone remodeling and osteoblast formation. PRP, known for its regenerative properties, was activated with collagen and divided into freeze-dried (FD PRP+C) and non-freeze-dried (PRP+C) groups. The results showed that the TGF-β1 level in the freeze-dried group was significantly higher than in the non-freeze-dried group (p<0.05). This indicated that the freeze-drying process enhanced the TGF-β1 levels in collagen-activated PRP, suggesting improved potential for tissue regeneration.

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