A Randomized Blinded Retrospective Study: The Combined Use of Micro-Needling Technique, Low-Level Laser Therapy, and Autologous Non-Activated Platelet-Rich Plasma Improves Hair Re-Growth in Patients with Androgenic Alopecia

July 2020 in “ Expert Opinion on Biological Therapy ”

Pietro Gentile, Laura Dionisi, Jacopo Pizzicannella, Barbara De Angelis, Domenico De Fazio, Simone Garcovich

micro-needling low-level laser therapy autologous non-activated platelet-rich plasma androgenic alopecia hair density microneedling LLLT PRP

TLDR Using micro-needling, low-level laser therapy, and platelet-rich plasma together significantly improves hair growth in people with hair loss.

In a retrospective study conducted in 2020, 23 patients with androgenic alopecia were treated with a combination of micro-needling technique, low-level laser therapy, and autologous non-activated platelet-rich plasma. The treatment led to a significant increase in hair density at 12 weeks and 58 weeks post-treatment. Specifically, there was a 31 ± 2% increase in hair density at 12 weeks and an increase of 23.3 ± 3 hairs/cm² at 58 weeks compared to baseline. The study concluded that this combined treatment significantly improved hair re-growth in patients with androgenic alopecia.

View this study on art.torvergata.it →

Discuss this study in the Community →

Research cited in this study

24 / 24 results

research Autologous Activated Platelet-Rich Plasma (AA-PRP) and Non-Activated (A-PRP) in Hair Growth: A Retrospective, Blinded, Randomized Evaluation in Androgenetic Alopecia

44 citations, February 2020 in “Expert Opinion on Biological Therapy”

PRP, especially AA-PRP, can help improve hair growth in androgenetic alopecia.

research Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia

41 citations, January 2020 in “BioMed Research International”

Micrografts improve hair density and thickness without side effects.

Low-Level Laser Therapy for the Treatment of Androgenetic Alopecia in Thai Men and Women: A 24-Week, Randomized, Double-Blind, Sham Device-Controlled Trial

research Low-Level Laser Therapy for the Treatment of Androgenetic Alopecia in Thai Men and Women: A 24-Week, Randomized, Double-Blind, Sham Device-Controlled Trial

45 citations, December 2018 in “Lasers in Medical Science”

LLLT promotes hair growth and improves hair density safely in men and women.

research Clinical Cosmeceutical Repurposing of Melatonin in Androgenic Alopecia Using Nanostructured Lipid Carriers Prepared with Antioxidant Oils

46 citations, September 2018 in “Expert Opinion on Drug Delivery”

Melatonin in special carriers can help treat hair loss.

research Melatonin Vitamin C-Based Nanovesicles for Treatment of Androgenic Alopecia: Design, Characterization and Clinical Appraisal

40 citations, July 2018 in “European Journal of Pharmaceutical Sciences”

Melatonin vitamin C-based nanovesicles improved hair growth and reduced hair loss in androgenic alopecia patients.

research Low-Level Laser Therapy for the Treatment of Androgenic Alopecia: A Review

41 citations, December 2017 in “Lasers in Medical Science”

Low-Level Laser Therapy (LLLT) is a safe and effective treatment for common hair loss, but more research is needed to find the best power and wavelength for treatment.

research Microneedling for the Treatment of Hair Loss

58 citations, December 2017 in “Journal of The European Academy of Dermatology and Venereology”

Microneedling can help stimulate hair growth, especially when used with other treatments, but it's not better than existing therapies.

Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

research Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

86 citations, June 2017 in “Stem cell investigation”

Stem cells from hair follicles can safely treat hair loss.

research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

178 citations, April 2017 in “Journal of The American Academy of Dermatology”

Minoxidil, finasteride, and low-level laser light therapy effectively treat hair loss.

research Novel Approach to Treating Androgenetic Alopecia in Females With Photobiomodulation (Low-Level Laser Therapy)

33 citations, March 2017 in “Dermatologic Surgery”

Low-level laser therapy effectively treats female hair loss, increasing hair count by 51%.

Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations, February 2017 in “International Journal of Molecular Sciences”

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

research Low-Level Laser Therapy as a Treatment for Androgenetic Alopecia

47 citations, April 2016 in “Lasers in Surgery and Medicine”

Low-level laser therapy may improve hair regrowth and thickness for androgenetic alopecia, but more research is needed.

research Microneedling as a Successful Treatment for Alopecia X in Two Pomeranian Siblings

12 citations, July 2015 in “Veterinary Dermatology”

Microneedling helped two Pomeranian dogs with a hair growth disorder grow back 90% of their fur in 12 weeks, and the results lasted for a year.

research The Growth of Human Scalp Hair in Females Using Visible Red Light Laser and LED Sources

81 citations, August 2014 in “Lasers in Surgery and Medicine”

Red light therapy is safe and effectively increases hair growth in women with hair loss.

research The Growth of Human Scalp Hair Mediated by Visible Red Light Laser and LED Sources in Males

117 citations, September 2013 in “Lasers in Surgery and Medicine”

Red light therapy at 655 nm significantly improved hair growth in men with hair loss.

research Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Sham Device-Controlled Multicenter Trial

106 citations, April 2013 in “Dermatologic Surgery”

Low-level light therapy safely improves hair growth and thickness for androgenetic alopecia.

research Caspase-1 Level Is Higher in the Scalp in Androgenetic Alopecia

27 citations, July 2012 in “Dermatologic Surgery”

Higher caspase-1 levels found in balding scalps; reducing it may help treat hair loss.

research Hair Growth and Rejuvenation: An Overview

81 citations, June 2010 in “Journal of Dermatological Treatment”

The document concludes that minoxidil and finasteride are proven for hair growth, herbal remedies show promise, but more research is needed to confirm their effectiveness.

research The Use of Low-Level Light for Hair Growth: Part I

90 citations, January 2009 in “Journal of cosmetic and laser therapy”

Low-level laser therapy might help hair growth, but more research is needed.

HairMax LaserComb Laser Phototherapy Device in the Treatment of Male Androgenetic Alopecia

research Finasteride and the Hair Cycle

26 citations, May 2000 in “Journal of The American Academy of Dermatology”

Finasteride improves hair growth.

Related Research

1 / 1 results

research Literature Review

March 2019 in “Hair transplant forum international”

The document's conclusion cannot be summarized because the content is not accessible or understandable.