A Randomized Blinded Retrospective Study: The Combined Use of Micro-Needling Technique, Low-Level Laser Therapy, and Autologous Non-Activated Platelet-Rich Plasma Improves Hair Re-Growth in Patients with Androgenic Alopecia

    July 2020 in “ Expert Opinion on Biological Therapy ”
    Pietro Gentile, Laura Dionisi, Jacopo Pizzicannella … Simone Garcovich
    Studysummary This study found that combining micro-needling, low-level laser therapy, and autologous non-activated platelet-rich plasma increased hair density in patients with androgenic alopecia over the treatment period.
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    Research cited in this study 26

    1. Autologous Activated Platelet-Rich Plasma (AA-PRP) and Non-Activated (A-PRP) in Hair Growth: A Retrospective, Blinded, Randomized Evaluation in Androgenetic Alopecia Expert Opinion on Biological Therapy · 2020
    2. Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia BioMed Research International · 2020
    3. Impact of Different Preparation Methods to Obtain Human Adipose-Derived Stromal Vascular Fraction Cells and Human Adipose-Derived Mesenchymal Stem Cells: Enzymatic Digestion Versus Mechanical Centrifugation International Journal of Molecular Sciences · 2019
    4. Low-Level Laser Therapy for the Treatment of Androgenetic Alopecia in Thai Men and Women: A 24-Week, Randomized, Double-Blind, Sham Device-Controlled Trial Lasers in Medical Science · 2018
    5. Clinical Cosmeceutical Repurposing of Melatonin in Androgenic Alopecia Using Nanostructured Lipid Carriers Prepared with Antioxidant Oils Expert Opinion on Drug Delivery · 2018
    6. Melatonin Vitamin C-Based Nanovesicles for Treatment of Androgenic Alopecia: Design, Characterization and Clinical Appraisal European Journal of Pharmaceutical Sciences · 2018
    7. Low-Level Laser Therapy for the Treatment of Androgenic Alopecia: A Review Lasers in Medical Science · 2017
    8. Microneedling for the Treatment of Hair Loss Journal of The European Academy of Dermatology and Venereology · 2017
    9. Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss Stem cell investigation · 2017
    10. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    11. Novel Approach to Treating Androgenetic Alopecia in Females With Photobiomodulation (Low-Level Laser Therapy) Dermatologic Surgery · 2017
    12. Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems International Journal of Molecular Sciences · 2017
    13. Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways Annals of Dermatology · 2017
    14. Low-Level Laser Therapy as a Treatment for Androgenetic Alopecia Lasers in Surgery and Medicine · 2016
    15. Microneedling as a Successful Treatment for Alopecia X in Two Pomeranian Siblings Veterinary Dermatology · 2015
    16. The Growth of Human Scalp Hair in Females Using Visible Red Light Laser and LED Sources Lasers in Surgery and Medicine · 2014
    17. The Growth of Human Scalp Hair Mediated by Visible Red Light Laser and LED Sources in Males Lasers in Surgery and Medicine · 2013
    18. Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Sham Device-Controlled Multicenter Trial Dermatologic Surgery · 2013
    19. Caspase-1 Level Is Higher in the Scalp in Androgenetic Alopecia Dermatologic Surgery · 2012
    20. Hair Growth and Rejuvenation: An Overview Journal of Dermatological Treatment · 2010
    21. The Use of Low-Level Light for Hair Growth: Part I Journal of cosmetic and laser therapy · 2009
    22. HairMax LaserComb Laser Phototherapy Device in the Treatment of Male Androgenetic Alopecia Clinical Drug Investigation · 2009
    23. Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle Journal of Dermatological Science · 2004
    24. Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle Journal of Cutaneous Medicine and Surgery · 2002
    25. Finasteride Increases Anagen Hair in Men with Androgenetic Alopecia British Journal of Dermatology · 2000
    26. Finasteride and the Hair Cycle Journal of The American Academy of Dermatology · 2000

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