Melatonin Vitamin C-Based Nanovesicles for Treatment of Androgenic Alopecia: Design, Characterization and Clinical Appraisal

    July 2018 in “ European Journal of Pharmaceutical Sciences ”
    Shymaa Hatem, Maha Nasr, Noha H. Moftah, Maha H. Ragai, Ahmed S. Geneidi, Seham A. Elkheshen
    TLDR Melatonin vitamin C-based nanovesicles improved hair growth and reduced hair loss in androgenic alopecia patients.
    The study developed vitamin C-based nanovesicles (aspasomes) loaded with melatonin to treat androgenic alopecia (AGA). These aspasomes were evaluated for their pharmaceutical properties and tested clinically on AGA patients. Results showed that melatonin aspasomes had favorable properties and significantly improved hair thickness, density, and reduced hair loss compared to melatonin solution. This indicated that melatonin vitamin C-based aspasomes were promising for treating AGA and potentially other oxidative-dependent dermatological diseases.
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