Clinical Cosmeceutical Repurposing of Melatonin in Androgenic Alopecia Using Nanostructured Lipid Carriers Prepared with Antioxidant Oils

    September 2018 in “ Expert Opinion on Drug Delivery ”
    Shymaa Hatem, Maha Nasr, Noha H. Moftah, Maha H. Ragai, Ahmed S. Geneidi, Seham A. Elkheshen
    TLDR Melatonin in special carriers can help treat hair loss.
    The study explored the repurposing of melatonin for treating androgenic alopecia by using nanostructured lipid carriers (NLCs) prepared with antioxidant oils. The research demonstrated that melatonin-loaded NLCs could enhance hair growth and reduce hair loss. The findings suggested that the antioxidant properties of the oils used in the NLCs contributed to the effectiveness of the treatment. This approach provided a novel and promising method for managing androgenic alopecia.
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      community Melatonin emerging as new treatment for androgenic alopecia?

      in Update  35 upvotes 1 year ago
      Melatonin is being considered as a potential treatment for androgenic alopecia, with some users discussing its effects and combining it with other treatments like minoxidil and finasteride. Concerns about melatonin's impact on hormones and side effects from other treatments like ketoconazole were also discussed.

      community Melatonin a possible tool to help fight AGA hair loss.

      in Research/Science  50 upvotes 4 years ago
      Topical melatonin may help reduce hair loss and increase hair thickness in people with androgenetic alopecia (AGA), with some studies showing positive results. It can be mixed with minoxidil for application, and its effectiveness might be enhanced when used with micro-needling, but results may vary among individuals.

      community Patent for topical resveratrol and melatonin for AGA

       6 upvotes 6 years ago
      The conversation discusses a patent for using topical resveratrol and melatonin to treat androgenetic alopecia (AGA) and also mentions interest in topical sulforaphane as a treatment.

      community any news about DUPA (Diffuse unpatterned alopecia)?

      in Research/Science  11 upvotes 3 years ago
      The conversation discusses diffuse unpatterned alopecia (DUPA) and its possible causes, including sensitivity to DHT, not being androgenic alopecia, being diffuse alopecia areata, or hormonal issues. Treatments mentioned include topical melatonin, Clobetasol Propionate for alopecia areata, and the lack of results from using finasteride, dutasteride, and minoxidil.

      community I feel like people here shrug off nutritional issues too quickly. Particularly for Retrograde Alopecia.

      in Chat  9 upvotes 3 years ago
      The user believes Retrograde Alopecia may be linked to vitamin imbalances, specifically from taking too much Vitamin E, A, Zinc, and Selenium, and suggests it could be a middle ground between Androgenic Alopecia and Telogen Effluvium. Treatments for hair loss mentioned include Androgen inhibitors and improving lifestyle factors like nutrition and sleep, with topical melatonin also recommended for Retrograde Alopecia.

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