Clinical Cosmeceutical Repurposing of Melatonin in Androgenic Alopecia Using Nanostructured Lipid Carriers Prepared with Antioxidant Oils

    September 2018 in “ Expert Opinion on Drug Delivery ”
    Shymaa Hatem, Maha Nasr, Noha H. Moftah, Maha H. Ragai, Ahmed S. Geneidi, Seham A. Elkheshen
    TLDR Melatonin in special carriers can help treat hair loss.
    The study explored the repurposing of melatonin for treating androgenic alopecia by using nanostructured lipid carriers (NLCs) prepared with antioxidant oils. The research demonstrated that melatonin-loaded NLCs could enhance hair growth and reduce hair loss. The findings suggested that the antioxidant properties of the oils used in the NLCs contributed to the effectiveness of the treatment. This approach provided a novel and promising method for managing androgenic alopecia.
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      community any news about DUPA (Diffuse unpatterned alopecia)?

      in Research/Science  11 upvotes 1 year ago
      The conversation discusses diffuse unpatterned alopecia (DUPA) and its possible causes, including sensitivity to DHT, not being androgenic alopecia, being diffuse alopecia areata, or hormonal issues. Treatments mentioned include topical melatonin, Clobetasol Propionate for alopecia areata, and the lack of results from using finasteride, dutasteride, and minoxidil.

      community I feel like people here shrug off nutritional issues too quickly. Particularly for Retrograde Alopecia.

      in Chat  9 upvotes 1 year ago
      The user believes Retrograde Alopecia may be linked to vitamin imbalances, specifically from taking too much Vitamin E, A, Zinc, and Selenium, and suggests it could be a middle ground between Androgenic Alopecia and Telogen Effluvium. Treatments for hair loss mentioned include Androgen inhibitors and improving lifestyle factors like nutrition and sleep, with topical melatonin also recommended for Retrograde Alopecia.

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 2 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community 1 month Pyrilutamide. A non responders story to everything.

      in Research/Science  218 upvotes 2 years ago
      My hairline, I am only 23. This conversation is about a user's experience with treatments for androgenic alopecia, including finasteride, dutasteride, RU, minoxidil, progesterone, melatonin, LLLT, oral minoxidil, and Pyrilutamide. They have tried many treatments over the course of two years without seeing much success, and they are considering getting a hair system as a last resort.

      community Do-it-yourself topical melatonin?

      in Product  12 upvotes 2 years ago
      The conversation is about creating homemade topical melatonin for hair loss, with one person suggesting adding melatonin to stemoxydine as a potential treatment.

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