The Combined Use of Platelet-Rich Plasma and Adipose-Derived Mesenchymal Stem Cells Promotes Healing: A Review of Experimental Models and Future Perspectives

    September 2021 in “ Biomolecules ”
    Dimitris Tatsis, Varvara Vasalou, Efstathios Kotidis, Elissavet Anestiadou, Ioannis Grivas, Angeliki Cheva, Georgios Koliakos, Gregory Venetis, Manousos-George Pramateftakis, Nikolaos Ouzounidis, Stamatios Angelopoulos
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    Studysummary This review examines experimental studies on the synergistic use of platelet-rich plasma and adipose-derived mesenchymal stem cells for wound healing in animal models, without reporting new clinical outcomes. Our plain-language summary of this paper — not a Tressless recommendation.
    The review paper discusses the combined use of Platelet-Rich Plasma (PRP) and Adipose-Derived Mesenchymal Stem Cells (ADMSCs) in promoting healing in various medical conditions. PRP, rich in growth factors, and ADMSCs, known for their regenerative properties, have shown promising results in experimental models, enhancing wound healing, bone regeneration, and hair growth. For instance, a study involving 55 canines with tendinopathy showed significant improvement after treatment with a mixture of ADMSCs and PRP. Another study reported that the combined use of PRP and ADMSCs injected in the scalp of patients with androgenic alopecia resulted in a time-related increase in hair density. However, more research is needed to fully understand the mechanisms involved, standardize the protocols for clinical use, and establish long-term efficacy and safety.
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