TLDR The conclusion is that fat grafting is safe and effective but carries risks that need careful management.
The document from July 1, 2016, reviews the use of autologous fat grafting, adipose-derived stem cells (ASCs), and platelet-rich plasma (PRP) in aesthetic and reconstructive surgery, emphasizing their potential to enhance graft retention and regenerative outcomes. It details the Coleman technique for fat grafting, which has become standardized, and discusses the importance of evidence-based practices and FDA compliance in the marketing of stem cell therapies. The document also notes the regenerative properties of fat grafts for improving skin quality and the treatment of scars, while cautioning against complications such as necrosis, cysts, and rare but serious events like embolization. Research on ASCs and PRP is still in its early stages, with studies showing promising results for fat graft retention and the treatment of alopecia, but more rigorous trials and long-term safety data are needed. The document concludes that while fat grafting is generally well-tolerated, it carries risks that must be carefully managed to ensure patient safety. Specific participant numbers for the studies mentioned are not provided in the summary.
214 citations,
September 2015 in “Stem Cells Translational Medicine” Platelet-rich plasma injections significantly improved hair regrowth and thickness in patients with hair loss.
66 citations,
June 2015 in “Aesthetic Plastic Surgery” Platelet preparations generally show positive effects on wound healing and facial rejuvenation, but more thorough research is needed to confirm their effectiveness.
74 citations,
January 2015 in “Asian Journal of Transfusion Science” Platelet-rich plasma (PRP) injections can effectively increase hair density and thickness in people with androgenic alopecia, without major side effects.
251 citations,
October 2006 in “Plastic and reconstructive surgery/PSEF CD journals” Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.
November 2023 in “Journal of cosmetic dermatology” Fat transplants using a patient's own fat can rejuvenate and repair tissues effectively.
2 citations,
September 2022 in “Cytotherapy” Fat-derived stem cells show promise for treating skin issues and improving wound healing, but more research is needed to confirm the best way to use them.
132 citations,
January 2017 in “International Journal of Molecular Sciences” Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.
62 citations,
October 2017 in “JAMA facial plastic surgery” Condensed nanofat with fat grafts effectively improves atrophic facial scars.
70 citations,
February 2021 in “International Journal of Molecular Sciences” Fat-derived stem cells, platelet-rich plasma, and biomaterials show promise for healing chronic skin wounds and improving soft tissue with few side effects.
