Fat, Stem Cells, and Platelet-Rich Plasma

The document from July 1, 2016, reviews the use of autologous fat grafting, adipose-derived stem cells (ASCs), and platelet-rich plasma (PRP) in aesthetic and reconstructive surgery, emphasizing their potential to enhance graft retention and regenerative outcomes. It details the Coleman technique for fat grafting, which has become standardized, and discusses the importance of evidence-based practices and FDA compliance in the marketing of stem cell therapies. The document also notes the regenerative properties of fat grafts for improving skin quality and the treatment of scars, while cautioning against complications such as necrosis, cysts, and rare but serious events like embolization. Research on ASCs and PRP is still in its early stages, with studies showing promising results for fat graft retention and the treatment of alopecia, but more rigorous trials and long-term safety data are needed. The document concludes that while fat grafting is generally well-tolerated, it carries risks that must be carefully managed to ensure patient safety. Specific participant numbers for the studies mentioned are not provided in the summary.