Osteocalcin Levels Evaluation of Freeze-Dried Homologous Platelet-Rich Plasma in Periodontal Treatment

This study evaluated the effect of freeze-dried homologous platelet-rich plasma (FD HPRP) on osteocalcin levels to support osteogenesis in periodontal treatment. FD HPRP was prepared using blood bank HPRP, freeze-drying, and γ-radiation at doses of 20 and 25 kGy. Osteoblasts (MG63 cell line) were treated with FD HPRP, and osteocalcin levels were measured using ELISA on days 7 and 14. Results showed a significant increase in osteocalcin levels, particularly with FD HPRP 25 kGy, indicating that FD HPRP can effectively support the osteogenesis process.