Effect of Composite Biodegradable Biomaterials on Wound Healing in Diabetes

The document reviewed the potential of composite biodegradable biomaterials in enhancing wound healing for diabetic patients, addressing challenges such as hypoxia, inflammation, and bacterial colonization. It explored the integration of these biomaterials with mesenchymal stem cells, drugs, and active factors to improve healing outcomes. Various strategies, including drug delivery systems and bioengineered skin substitutes, were discussed, with studies involving up to 880 subjects showing effectiveness. The research highlighted the antibacterial, anti-inflammatory, and pro-angiogenic properties of materials like chitosan and glycopeptide hydrogels. Despite promising results, the transition to clinical application faced challenges due to differences in wound healing mechanisms between animal models and humans, ethical concerns, and the complexity of clinical situations. The document underscored the need for further studies to facilitate clinical translation and improve diabetic wound healing.