TLDR Composite biodegradable biomaterials can improve diabetic wound healing but need more development for clinical use.
This review highlights the potential of composite biodegradable biomaterials in enhancing diabetic wound healing by integrating materials, cells, and growth factors. These biomaterials exhibit strong biocompatibility and promote healing through the regulation of immune responses, inflammation, angiogenesis, skin cell proliferation, re-epithelialization, and collagen remodeling. The integration with drugs, stem cells, and active agents allows for precise drug delivery and controlled release. However, the clinical application of these materials is limited by their current functionality, and further development is needed to achieve stable and effective clinical transformation.
23 citations
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November 2021 in “Journal of Bionic Engineering” The new wound dressing helps skin heal faster and fights infection.
34 citations
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May 2021 in “Journal of Nanobiotechnology” The 3D electrospun fibrous sponge is promising for tissue repair and healing diabetic wounds.
83 citations
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May 2021 in “Biomolecules” The 5/G hydrogel effectively improves diabetic wound healing.
124 citations
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June 2020 in “Cell Stem Cell” Fat cells in the skin help start healing and form important repair cells after injury.
3 citations
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January 2020 in “PubMed” Adding insulin-like growth factor 1 and bone marrow-derived stem cells to a collagen-chitosan scaffold helps wounds heal faster and regrows hair follicles.
211 citations
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November 2018 in “Nature Cell Biology” Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.
2 citations
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May 2023 in “Frontiers in Bioengineering and Biotechnology” The document concludes that more research is needed on making and understanding biomaterial scaffolds for wound healing.
1 citations
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February 2024 in “Journal of nanobiotechnology” Hydrogels combined with extracellular vesicles and 3D bioprinting improve wound healing.
6 citations
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February 2023 in “Biomaterials Research” Special gels help heal diabetic foot sores and reduce the risk of amputation or death.
1 citations
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February 2023 in “International Journal of Molecular Sciences” The fascial layer is a promising new target for wound healing treatments using biomaterials.
30 citations
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February 2022 in “Pharmaceutics” 3D bioprinting improves wound healing by precisely creating scaffolds with living cells and biomaterials, but faces challenges like resolution and speed.
