Multifunctional Injectable Hydrogel Loaded With Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing

The study developed a multifunctional injectable hydrogel by incorporating cerium-containing bioactive glass (Ce-BG) into Gelatin methacryloyl (GelMA) hydrogel to address diabetic foot wound healing challenges. The Ce-BG/GelMA hydrogels demonstrated good cytocompatibility, promoted endothelial cell migration and tube formation, and exhibited excellent antibacterial properties, particularly with 5 mol % CeO2-containing bioactive glass/GelMA (5/G) composite hydrogel. In vivo studies on diabetic rats showed that the 5/G hydrogel significantly improved wound healing by accelerating granulation tissue formation, collagen deposition, and angiogenesis. These findings suggested that the 5/G hydrogel could effectively enhance diabetic wound healing, highlighting the importance of developing materials with both antibacterial and angiogenic functions.