Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair

    June 2020 in “ Cell Stem Cell ”
    Brett A. Shook, Renee R. Wasko, Omer Mano, Michael Rutenberg-Schoenberg, Michael C. Rudolph, Bahar Zirak, Guillermo C. Rivera-Gonzalez, Francesc López-Giráldez, Simona Zarini, Amélie Rezza, Damon A. Clark, Michael Rendl, Michael D. Rosenblum, Mark Gerstein, Valerie Horsley
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    Studysummary This study found that in mice, dermal adipocytes initiate inflammation and aid repair after skin injury by releasing lipids, suggesting a role in managing inflammatory diseases and impaired wound healing. Our plain-language summary of this paper — not a Tressless recommendation.
    The study conducted by Shook et al. in 2020 found that lipolysis in dermal adipocytes is essential for initiating inflammation and promoting skin repair after injury. In experiments using genetic mouse models, it was discovered that adipocytes near skin wounds release lipids that are necessary for macrophage-driven inflammation. Inhibiting lipolysis led to fewer inflammatory macrophages and delayed wound repair. Furthermore, adipocyte-derived cells were shown to dedifferentiate and contribute to the formation of myofibroblasts, which are crucial for healing. The study, which included 3 to 7 mice per condition, suggests that adipocytes play a significant role in skin repair by regulating inflammation and contributing to the extracellular matrix, with potential therapeutic implications for inflammatory diseases and wound healing disorders.
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