TLDR Adipocytes can change into fibroblast-like cells to help with wound healing.
This study explores the plasticity of adipocytes, showing that they can dedifferentiate into fibroblast-like cells, particularly around skin wounds. Using a two-step lineage tracing method, researchers identified Pdgfra+ cells originating from Adipoq+ adipocytes. They observed that these cells, which incorporate EdU and alter their marker expression, are prevalent around wound edges but sparse at the center. The study also found that PDGF and TGFβ signaling promote this dedifferentiation, with PDGFRα acting independently of TGFβR2. These findings highlight the potential role of dedifferentiated adipocytes in wound repair, regeneration, and fibrosis.
Cited in this study
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124 citations
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June 2020 in “Cell Stem Cell” Fat cells in the skin help start healing and form important repair cells after injury.
301 citations
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February 2019 in “Nature Communications” The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.
408 citations
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February 2017 in “Science” Some wound-healing cells can turn into fat cells around new hair growth in mice.
106 citations
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December 2016 in “Cell Stem Cell” PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.
75 citations
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October 2016 in “Genes & Development” Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.
218 citations
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October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.
238 citations
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April 2013 in “Development” Fat cells help recruit healing cells and build skin structure during wound healing.
499 citations
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September 2011 in “Cell” Fat-related cells are important for initiating hair growth.