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    Regulation of Adipocyte Dedifferentiation at the Skin Wound Edge

    November 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Longbiao Yao, Sunhye Jeong, Hae Ryong Kwon, Lorin E. Olson

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that mature adipocytes can dedifferentiate into fibroblast-like cells, driven by PDGF and TGFβ signaling, which may play a role in wound repair and fibrosis.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 10

    1. Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair Cell Stem Cell · 2020
    2. Dermal Adipose Tissue Has High Plasticity And Undergoes Reversible Dedifferentiation In Mice Journal of Clinical Investigation · 2019
    3. Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds Nature Communications · 2019
    4. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    5. Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT Signaling Axis Cell Stem Cell · 2016
    6. Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog Genes & Development · 2016
    7. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    8. Lipoatrophy and Severe Metabolic Disturbance in Mice with Fat-Specific Deletion of PPARγ Proceedings of the National Academy of Sciences of the United States of America · 2013
    9. Intradermal Adipocytes Mediate Fibroblast Recruitment During Skin Wound Healing Development · 2013
    10. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011