The Bright Side of Fibroblasts: Molecular Signature and Regenerative Cues in Major Organs

    August 2021 in “ npj Regenerative Medicine ”
    Rita N. Gomes, Filipa Manuel, Diana S. Nascimento
    Image of study
    TLDR Fibroblasts, cells usually linked to tissue repair, also help regenerate various organs and their ability decreases with age. Turning adult fibroblasts back to a younger state could be a new treatment approach.
    The review article discusses the pro-regenerative role of fibroblasts in various organs, including skin, liver, lung, kidney, and heart. Fibroblasts, traditionally associated with tissue repair, are now recognized for maintaining stem cell niches and guiding the regenerative process through the secretion of molecules that promote cell adhesion, migration, and proliferation. The authors suggest a new therapeutic approach based on reverting adult fibroblasts to a fetal/neonatal-like phenotype. The document also highlights the decrease in fibroblasts' regenerative capacity with aging. In the context of hair follicle renewal, the stimulation of fibroblast-mediated Wnt or Shh signaling may be a promising strategy. The document concludes that further studies are needed to identify cellular subpopulations that contribute mostly to regeneration instead of repair.
    Discuss this study in the Community →

    Research cited in this study

    17 / 17 results

    Related Community Posts Join

    6 / 33 results

      community Verteporfin and Microneedling

      in Treatments 1 year ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

    Related Research

    1 / 1 results