Fibroblast State Switching Orchestrates Dermal Maturation and Wound Healing

August 2018 in “ Molecular Systems Biology ”

Emanuel Rognoni, Angela Oliveira Pisco, Toru Hiratsuka, Kalle Sipilä, Julio M. Belmonte, S A Mobasseri, Christina Philippeos, Rui Dilão, Fiona M. Watt

fibroblast extracellular matrix ECM dermal maturation wound healing in vivo imaging lineage tracing computational modeling proliferative state quiescent state tissue remodeling skin integrity skin repair skin healing skin development skin function

Studysummary This study found that in murine dermis, fibroblast state switching between proliferation and ECM deposition plays a crucial role in tissue architecture and wound healing.

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research Fibroblast State Switching Orchestrates Dermal Maturation and Wound Healing

126 citations , August 2018 in “Molecular Systems Biology”

This study found that in murine dermis, fibroblast state switching between proliferation and ECM deposition plays a crucial role in tissue architecture and wound healing.

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This study identified at least four distinct fibroblast populations in adult human skin, each with unique functional properties, suggesting potential therapeutic applications for wound healing and fibrosis-related diseases.

research Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth

85 citations , June 2017 in “Journal of Investigative Dermatology”

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research Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties

143 citations , May 2017 in “Nature cell biology”

This study found that the transcription factor Gata6 regulates the sebaceous duct lineage identity and plays a crucial role in epidermal wound healing by enabling dedifferentiation and broader lineage capabilities in post-mitotic cells.

research Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis

363 citations , March 2017 in “Nature Communications”

This study found that, in mouse tail epidermis, stem cells rapidly activate and regenerate new progenitors to repair wounds, with mechanisms affecting their proliferation, differentiation, and migration.

research Regeneration of Fat Cells from Myofibroblasts During Wound Healing

408 citations , January 2017 in “Science”

This study found that hair follicles in mice and humans can convert wound-related myofibroblasts into adipocytes, suggesting a potential pathway to reduce scar formation by activating BMP signaling.

research Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages

115 citations , February 2016 in “Nature Communications”

The authors concluded that the dermal response to epidermal Wnt/β-catenin signaling depends on distinct fibroblast lineages, with each responding to different paracrine signals such as Hedgehog and TGF-β.

research Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing

87 citations , January 2016 in “Development”

This study suggests that the postnatal loss of hair follicle formation in wounds may be due to elevated Wnt/β-catenin activation in the dermis, affecting fibroblast function in mice.

research Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors

130 citations , March 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that in mice, epidermal Wnt/β-catenin signaling influences adipocyte differentiation and hair growth, suggesting its critical role in synchronizing adipogenesis with the hair growth cycle.

research Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair

1235 citations , December 2013 in “Nature”

This study found that skin fibroblasts in mice arise from two distinct lineages which contribute differently to dermal structure and repair, impacting hair follicle formation during wound healing.

research Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin

128 citations , October 2011 in “Development”

This study found that adult mouse dermis can be reprogrammed by epidermal cues to resemble neonatal dermis, with changes in fibroblast proliferation and extracellular matrix composition.

research More Than One Way to Skin

218 citations , April 2008 in “Genes & Development”

This research discusses how epithelial stem cells in the skin maintain normal homeostasis, contribute to wound repair, and highlights the importance of these processes, as defects can lead to skin diseases including cancers, but provides no new experimental results.