Fibroblast State Switching Orchestrates Dermal Maturation and Wound Healing

August 2018 in “ Molecular Systems Biology ”

Emanuel Rognoni, Angela Oliveira Pisco, Toru Hiratsuka, Kalle Sipilä, Julio M. Belmonte, S A Mobasseri, Christina Philippeos, Rui Dilão, Fiona M. Watt

fibroblast extracellular matrix ECM dermal maturation wound healing in vivo imaging lineage tracing computational modeling proliferative state quiescent state tissue remodeling skin integrity skin repair skin healing skin development skin function

TLDR Fibroblast state switching is crucial for skin healing and development.

The study demonstrated that fibroblast state switching, regulated by extracellular matrix (ECM) deposition, played a crucial role in dermal maturation and wound healing. Using in vivo imaging, lineage tracing, and computational modeling, researchers found that fibroblasts transitioned between proliferative and quiescent states, with ECM negatively regulating proliferation. This switch was essential for effective wound healing and proper dermal development, as fibroblasts migrated to the wound bed, proliferated, and then entered a quiescent state to facilitate ECM production and tissue remodeling. The findings highlighted the dynamic nature of fibroblasts and their importance in maintaining skin integrity and function, suggesting potential therapeutic targets for improving skin repair and treating related disorders.