TLDR Fibroblast state switching is crucial for skin healing and development.
The study demonstrated that fibroblast state switching, regulated by extracellular matrix (ECM) deposition, played a crucial role in dermal maturation and wound healing. Using in vivo imaging, lineage tracing, and computational modeling, researchers found that fibroblasts transitioned between proliferative and quiescent states, with ECM negatively regulating proliferation. This switch was essential for effective wound healing and proper dermal development, as fibroblasts migrated to the wound bed, proliferated, and then entered a quiescent state to facilitate ECM production and tissue remodeling. The findings highlighted the dynamic nature of fibroblasts and their importance in maintaining skin integrity and function, suggesting potential therapeutic targets for improving skin repair and treating related disorders.
126 citations,
August 2018 in “Molecular Systems Biology” Fibroblast state switching is crucial for skin healing and development.
143 citations,
May 2017 in “Nature cell biology” Wounded skin cells can revert to stem cells and help heal.
408 citations,
January 2017 in “Science” Some wound-healing cells can turn into fat cells around new hair growth in mice.
87 citations,
January 2016 in “Development” Blocking β-catenin in skin cells improves hair growth during wound healing.
130 citations,
March 2014 in “Proceedings of the National Academy of Sciences of the United States of America” Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.
128 citations,
October 2011 in “Development” Activating a protein called β-catenin in adult skin can make it behave like young skin, potentially helping with skin aging and hair loss.
8 citations,
January 2022 in “Burns and trauma” Skin cell-derived vesicles can help heal skin injuries effectively.
2 citations,
September 2023 in “International journal of molecular sciences” Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.
January 2019 in “Advances in stem cells and their niches” Skin health and repair depend on the signals between skin stem cells and their surrounding cells.
1 citations,
August 2023 in “The Journal of Pathology” Different types of skin fibroblasts have unique roles in skin health and disease.
January 2023 in “Open veterinary journal” Cow blood vessel cell secretions helped heal rat burn wounds and may treat burns and hair loss.
