Secretome of Bovine Umbilical Vein Endothelial Cells Promotes Wound Healing Regeneration in Second Degree Rat Model Burn Injury

    January 2023 in “ Open veterinary journal ”
    Mavheena Moghan, P. Naidu, Nadhrah Zulkifly, Yulfia N. Selan, Erif Maha Nugraha Setyawan, Sugi Winarsih, Dwi Liliek Kusindarta
    From the encyclopedia
    collagen →
    Vascular Endothelial Growth Factor →
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    Studysummary This study observed that applying a cream containing secretome from Bovine Umbilical Vein Endothelial Cells promoted healing and regeneration in burn wounds in rats, particularly at a 15% concentration. Our plain-language summary of this paper — not a Tressless recommendation.
    The study assessed the impact of bovine umbilical vein endothelial cell (BUVEC) secretome on healing second-degree burn wounds in rats. The 48 rats were divided into four groups, receiving different concentrations of BUVEC-conditioned medium (CM) cream or povidone-iodine as a control. The BUVEC-CM was applied twice daily for 29 days, and the 15% BUVEC-CM group exhibited significant improvements in wound closure, epithelial repair, fibroblast and collagen increase, and blood vessel formation. The BUVEC secretome was found to promote fibroblast regeneration, collagen formation, re-epithelialization, and hair follicle regeneration, suggesting its potential as a treatment for burns and possibly alopecia. The study highlights the presence of growth factors like VEGF and bFGF in the BUVEC-CM, which are key to the observed wound healing and tissue regeneration effects.
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