Application of Genetically Modified Umbilical Cord Blood Cells and Direct Gene Therapy for Treatment of Skin Wounds in Rats

    September 2014 in “ Genes and Cells ”
    И. М. Газизов, И. И. Салафутдинов, M. O Mavlikeev, F. V Bashirov, Р. Р. Исламов, Albert A. Rizvanov, A. P Kiassov
    TLDR Genetically modified umbilical cord blood cells improved skin wound healing in rats.
    The study investigated the use of genetically modified umbilical cord blood cells for treating skin wounds in rats. Researchers transplanted hematopoietic stem cells from umbilical cord blood, modified with VEGF and FGF2 genes, into full-thickness skin wounds of 10 rats. The results showed that these modified cells participated in wound regeneration, with evidence of differentiation into keratinocytes and endothelial cells. The experimental group exhibited a lower proliferation rate of keratinocytes compared to the control group, indicating more complete wound healing. The study concluded that transfecting umbilical cord blood cells with VEGF and FGF2 genes accelerated skin wound regeneration, suggesting potential therapeutic applications for chronic ischemia and trophic ulcers.
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