TLDR Transfected cells with VEGF and FGF2 genes improve skin wound healing by enhancing blood flow and regeneration.
The study investigated the effects of gene and cell therapy on skin wound healing in 20 male Wistar rats using human umbilical cord blood mononuclear cells (hUCB-MC) transfected with VEGF and FGF2 genes. The transfected cells enhanced wound healing by promoting revascularization and reducing proliferative processes earlier than untransfected cells. The dual gene expression plasmid pBud-VEGF165-FGF2 was effective in direct gene therapy, significantly increasing the expression of VEGF and FGF2 genes, which are crucial for angiogenesis. The study concluded that hUCB-MC transfected with these genes could be a promising approach for treating skin wounds, as they accelerated regeneration and improved blood flow, protecting skin flaps from ischemic injury.
38 citations
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December 2019 in “Iranian Biomedical Journal” Hair follicle stem cells help burns heal faster and stronger.
129 citations
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July 2019 in “Stem Cell Research & Therapy” Epidermal stem cells help heal severe skin wounds and have potential for medical treatments.
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May 2019 in “Medicinal Research Reviews” Combining stem cells and targeted treatments can improve muscle and skin healing after cleft repair.
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August 2022 in “Molecular Therapy — Nucleic Acids” Gene therapy shows promise for healing chronic wounds but needs more research to overcome challenges.
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December 2022 in “Frontiers in Bioengineering and Biotechnology” Extracellular vesicles show promise for wound healing, but more research is needed to improve their stability and production.
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May 2023 in “Gels” Chitosan hydrogels are promising for repairing blood vessels but need improvements in strength and compatibility.
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October 2017 in “Biomolecules” Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.
January 2012 in “Elsevier eBooks” New treatments for skin and hair repair show promise, but further improvements are needed.
