Influence of Recombinant Codon-Optimized Plasmid DNA Encoding VEGF and FGF2 on Co-Induction of Angiogenesis
February 2021
in “
Cells
”
New to Vascular Endothelial Growth Factor? There is a guide in the encyclopedia. Read the guide → Studysummary This study concluded that using human umbilical cord blood mononuclear cells transfected with VEGF and FGF2 genes enhances skin wound healing in rats, demonstrating greater wound revascularization compared to controls.
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The study investigated the effects of gene and cell therapy on skin wound healing in 20 male Wistar rats using human umbilical cord blood mononuclear cells (hUCB-MC) transfected with VEGF and FGF2 genes. The transfected cells enhanced wound healing by promoting revascularization and reducing proliferative processes earlier than untransfected cells. The dual gene expression plasmid pBud-VEGF165-FGF2 was effective in direct gene therapy, significantly increasing the expression of VEGF and FGF2 genes, which are crucial for angiogenesis. The study concluded that hUCB-MC transfected with these genes could be a promising approach for treating skin wounds, as they accelerated regeneration and improved blood flow, protecting skin flaps from ischemic injury.
