Stem Cell-Derived Secretome: A Novel Strategy for Wound Healing

    June 2026 in “ Frontiers in Pharmacology ”
    Patrícia Sousa, Ana Sousa, Alícia Moreira … Ana Colette Maurício
    Studysummary This review highlights the potential of stem cell-derived secretome as a promising cell-free approach for wound healing, offering advantages over live cell therapies in terms of safety, scalability, and storage.
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    Research cited in this study 8

    1. Synergistic Effects of Mesenchymal Stem Cells and Their Secretomes with Scaffolds in Burn Wound Healing: A Systematic Review and Meta-Analysis of Preclinical Studies Journal of Translational Medicine · 2025
    2. Rat Hair Follicle Stem Cell-Derived Exosomes: Isolation, Characterization, and Comparative Analysis of Their In Vitro Wound Healing Potential International Journal of Molecular Sciences · 2025
    3. Umbilical Cord-Derived Mesenchymal Stem Cell Secretome Promotes Skin Regeneration and Rejuvenation: From Mechanism to Therapeutics Cell proliferation · 2023
    4. Stem Cell-Derived Exosomes: Emerging Therapeutic Opportunities for Wound Healing Stem cell research & therapy · 2023
    5. Secretome of Bovine Umbilical Vein Endothelial Cells Promotes Wound Healing Regeneration in Second Degree Rat Model Burn Injury Open veterinary journal · 2023
    6. Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway Stem Cell Research & Therapy · 2020
    7. Epidermal Stem Cells in Wound Healing and Regeneration Stem Cells International · 2020
    8. Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine International Journal of Molecular Sciences · 2017