Stem Cell-Derived Exosomes: Emerging Therapeutic Opportunities for Wound Healing

    April 2023 in “ Stem cell research & therapy ”
    Chuchao Zhou, Boyu Zhang, Yanqing Yang, Qiong Jiang, Tianyu Li, Jun Gong, Huiping Tang, Qi Zhang
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    TLDR Tiny vesicles from stem cells could be a new treatment for healing wounds.
    The review highlights the promising therapeutic potential of mesenchymal stem cell-derived exosomes (MSC-exos) in wound healing. These exosomes, which are small vesicles 30-150 nm in size, offer advantages over traditional MSCs due to their lower immunogenicity, ease of storage, and effective biological activity. Derived from sources like adipose tissue, bone marrow, and umbilical cords, MSC-exos influence skin cells, enhance angiogenesis, modulate immune responses, and inhibit apoptosis. They are particularly effective in treating diabetic wounds, inflammatory wound repair, and preventing keloid formation. The review underscores the need for further research to understand the specific roles and mechanisms of MSC-exos to develop them as a promising cell-free therapeutic option for wound healing and skin regeneration.
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