Stem Cell-Derived Exosomes: Emerging Therapeutic Opportunities for Wound Healing
April 2023
in “
Stem cell research & therapy
”
mesenchymal stem cell-derived exosomes MSC-exos adipose-derived stem cells bone marrow-derived MSCs human umbilical cord MSCs fibroblasts keratinocytes immune cells endothelial cells diabetic wounds inflammatory wound repair keloid formation stem cell exosomes fat-derived stem cells bone marrow stem cells umbilical cord stem cells skin cells wound healing
TLDR Tiny vesicles from stem cells could be a new treatment for healing wounds.
The review highlights the promising therapeutic potential of mesenchymal stem cell-derived exosomes (MSC-exos) in wound healing. These exosomes, which are small vesicles 30-150 nm in size, offer advantages over traditional MSCs due to their lower immunogenicity, ease of storage, and effective biological activity. Derived from sources like adipose tissue, bone marrow, and umbilical cords, MSC-exos influence skin cells, enhance angiogenesis, modulate immune responses, and inhibit apoptosis. They are particularly effective in treating diabetic wounds, inflammatory wound repair, and preventing keloid formation. The review underscores the need for further research to understand the specific roles and mechanisms of MSC-exos to develop them as a promising cell-free therapeutic option for wound healing and skin regeneration.
