Umbilical Cord-Derived Mesenchymal Stem Cell Secretome Promotes Skin Regeneration and Rejuvenation: From Mechanism to Therapeutics

The document reviews the therapeutic potential of umbilical cord-derived mesenchymal stem cell (UCMSC) secretome for skin regeneration and rejuvenation. The UCMSC secretome, which includes proteins, exosomes, and other bioactive factors, promotes wound healing by enhancing cell proliferation, angiogenesis, and reducing inflammation and fibrosis. It shows promise in treating chronic wounds, alopecia, and skin aging, with 86.6% of subjects showing positive results in hair regeneration. The secretome's efficacy is enhanced when combined with treatments like microneedling and radiofrequency. Despite its advantages, such as lower immunogenicity and cost-effectiveness, concerns about biosafety and variability due to donor differences remain. Overall, the UCMSC secretome is a promising non-drug, non-steroidal treatment for various skin conditions.