Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

    March 2020 in “ Advanced functional materials ”
    Meadhbh Á. Brennan, Pierre Layrolle, David J. Mooney
    Image of study
    TLDR Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.
    The document from March 11, 2020, reviews the potential of mesenchymal stromal cell (MSC) secretions, particularly extracellular vesicles (EVs) and soluble factors, for tissue regeneration. It explains that while MSC transplantation has shown benefits for tissue repair, the therapeutic effects are mainly due to paracrine actions rather than cell engraftment. The review details how EVs and soluble factors can modulate immune responses and promote regeneration through their nucleic acid and protein content. However, due to rapid clearance of EVs when administered directly, biomaterials are being developed to enhance their retention and therapeutic efficacy. The authors discuss methods to increase the potency of the MSC secretome, including cell culture manipulation and genetic modification of MSCs. Advances in EV-functionalized biomaterials are presented, which show improved angiogenesis, cell survival, and reduced inflammation and fibrosis. The document also addresses challenges in clinical translation, such as standardization and scalability, and suggests that MSC secretome-based therapies could offer advantages over cell therapy, including the possibility of filter sterilization, extended stability, and reduced manufacturing costs.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 13 results

      community This guy claims stem cells fixed his balding

      in Is this regrowth?  301 upvotes 1 year ago
      A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.

      community Mesenchymal Stem Cell Therapy (Exosome) Before & After

      in Treatment  2 upvotes 8 months ago
      A user's father experienced hair regrowth and other health improvements after two IV exosome treatments. The user also had four rounds of exosome therapy, noting significant hair regrowth and relief from headaches, but no change in gray hair.

      community 1.5 Year Hair Restoration Journey - Stem Cells, PRP, Minoxidil, Topical Finasteride

      in Progress Pictures  27 upvotes 10 months ago
      A user shared their 1.5-year hair restoration journey, successfully using mesenchymal stem cell therapy, Platelet Rich Plasma (PRP) injections, and a topical compound of finasteride and minoxidil, avoiding a hair transplant and oral finasteride. They experienced significant hair regrowth, particularly crediting the stem cell therapy for quick initial results.

      community Lavdik Hair Growth Serum?

      in Product 4 years ago
      A user is concerned about the legitimacy of a hair growth serum called Lavdik, which they ordered after seeing an ad for Jemros. The product contains ginger extract, ginseng extract, fleece flower root, grape seed oil, glycerol, carbomer, propylene glycol, and rosemary oil, and the user is unsure if it is effective or a scam.

      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 2 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

    Similar Research

    5 / 1000+ results