Recent Advances in Exosomal Non-Coding RNA-Based Therapeutic Approaches for Photoaging
September 2023
in “
Skin research and technology
”
exosomal non-coding RNA photoaging ultraviolet radiation mesenchymal stem cells exosomes non-coding RNAs skin rejuvenation adipose-derived stem cells hair follicle stem cells TGF-β MAPK BMP collagen degradation tumor progression wrinkles skin elasticity skin damage UVR MSCs ADSCs TGF-beta MAP kinase bone morphogenetic proteins
TLDR New treatments for skin damage from UV light using stem cells and their secretions show promise for skin repair without major risks.
The paper reviews recent advances in using exosomal non-coding RNA-based therapies for treating photoaging caused by ultraviolet radiation (UVR). It highlights the potential of mesenchymal stem cells (MSCs) and their derivatives, such as exosomes and non-coding RNAs, in skin rejuvenation by avoiding immune rejection and granuloma formation. The review covers various stem cells, including adipose-derived stem cells (ADSCs) and hair follicle stem cells, which secrete factors that repair aging skin tissues. Key signaling pathways like TGF-β, MAPK, and BMP are involved, with UVR causing mutations that promote collagen degradation and tumor progression. Exosomes, due to their non-immunogenic properties, show promise in reducing wrinkles, increasing elasticity, and repairing skin damage, suggesting significant clinical potential for these therapies in preventing and controlling photoaging.
