Hydrogel-Based Skin Regeneration

The document reviews the use of hydrogel-based materials in skin regeneration, emphasizing their ability to mimic the extracellular matrix, retain moisture, and support cell migration and tissue regeneration. Hydrogels, made from hydrophilic polymers, offer benefits such as oxygen permeability, wound exudate absorption, and the delivery of therapeutic agents. The review highlights various natural and synthetic polymers, including chitosan, hyaluronic acid, gelatin, and alginate, for their biocompatibility and regenerative properties. It discusses the role of hydrogels in promoting cell proliferation, reducing inflammation, and facilitating re-epithelialization and angiogenesis. The document also explores the potential of hybrid hydrogels and innovative material designs to enhance wound healing, particularly for diabetic and burn wounds, and underscores the need for advanced wound dressings that combine physical protection with regenerative capabilities.