Bioactive Molecules for Skin Repair and Regeneration: Progress and Perspectives

The 2019 review article discussed the potential of bioactive molecules in skin regenerative medicine, focusing on their ability to regulate cellular processes and promote the differentiation of stem cells into various skin cells such as keratinocytes, endothelial cells, and hair follicle stem cells. It highlighted the progress in using these molecules to generate desired cell types in vitro for cell therapy and to activate the body's endogenous repair mechanisms in vivo. The review also addressed the challenges in the field, including the low efficiency of chemical-based reprogramming, the need for suitable bioactive molecules for in situ skin repair, and the discrepancy between in vitro and in vivo results. It emphasized the importance of understanding molecular mechanisms, developing safe and efficient delivery systems, and using biomaterials for controlled release of therapeutic agents. The review concluded that with advancements in understanding regenerative mechanisms and high-throughput screening technologies, bioactive molecule-based tissue regeneration could overcome current hurdles and improve human health.