Chitosan/LiCl Composite Scaffolds Promote Skin Regeneration in Full-Thickness Loss
January 2019
in “
Science China Life Sciences
”
Chitosan LiCl composite scaffolds skin regeneration full-thickness skin wounds cytocompatibility biodegradation angiogenesis re-epithelialization hair follicles keratinocyte proliferation keratinocyte migration Wnt signaling pathway wound healing chitosan lithium chloride scaffolds skin repair wounds cell compatibility biodegradable blood vessel formation skin cell growth hair growth skin cell proliferation skin cell migration Wnt pathway healing
TLDR Chitosan/LiCl composite scaffolds help heal deep skin wounds better.
The study from January 28, 2019, investigated the effects of Chitosan/LiCl (CLiS) composite scaffolds on skin regeneration in full-thickness skin wounds. The in vitro assessments showed that CLiS had favorable properties such as cytocompatibility, swelling, and biodegradation. In vivo experiments on male C57BL/c mice demonstrated that wounds treated with CLiS had reduced inflammation, improved angiogenesis, accelerated re-epithelialization, and some regenerated hair follicles, compared to control and Chitosan scaffold (CS) groups. The scaffolds also promoted keratinocyte proliferation and migration, and activated the Wnt signaling pathway, which is crucial for wound healing. The study concluded that CLiS scaffolds could regulate the entire skin repair process and may be a promising strategy for treating both acute and chronic wounds. However, the number of mice used in the experiment was not specified.
