Scaffolds for Epithelial and Hair Follicle Regeneration

    January 2019 in “ Elsevier eBooks ”
    Herminio Torres, Hongjun Wang
    Image of study
    TLDR Electrospun matrices help regenerate skin and hair follicles using PCL and collagen scaffolds.
    This document discusses the challenges of repairing full-thickness skin wounds and the use of tissue-engineered skin grafts, specifically electrospun matrices, for regenerating skin and hair follicles. The document explores the importance of the extracellular matrix (ECM) in influencing cell behavior and phenotype for skin and hair follicle regeneration. It also discusses the use of scaffolds made of PCL and collagen for epithelial and hair follicle regeneration. The method involves layer-by-layer assembly of the multilayer and multicell construct, with the selective placement of DP aggregates allowing for an esthetically pleasing arrangement of hair follicles.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 1000+ results

      community Verteporfin and Microneedling

      in Treatments 5 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Comprehensive Microneedling Guide

      in Microneedling  290 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 2 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

      in Treatment  92 upvotes 4 years ago
      Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.

    Related Research

    5 / 5 results