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In this study, fibronectin coating on a low-adhesive substratum increased cell aggregation, growth, and motility, enhancing the formation of hair follicle dermal papilla spheroids.

This study observed that dermal papilla cell aggregates showed increased viability and gene expression on softer 3D substrates, indicating the importance of substrate stiffness in cellular behavior.

This study found that dermal papilla-like tissue reconstructed using canine adipose-derived mesenchymal stem cells closely resembles actual canine dermal papilla cells in both morphology and molecular characteristics.

This study found that human dermal papilla cells are embedded in a basement membrane-like extracellular matrix, which is essential for their aggregation and function, as supported by evidence that Matrigel enhances dermal papilla cohesion and gene expression compared to collagen I, which promotes cell dispersion.

This study achieved a first by successfully forming large quantities of dermal papilla spheroidal microtissues, which retained their hair induction potential, using a micropatterned culture system.