TLDR The research found ways to activate melanocyte stem cells for potential treatment of skin depigmentation conditions.
The study explored methods to activate melanocyte stem cells (McSCs) for hair follicle regeneration in mice and to create an immortalized cell line of melanocyte progenitors from neonatal mouse skin. The in vivo approach used 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce McSCs regeneration, migration, and differentiation, while the in vitro method developed a culture system for these progenitors. The research aimed at understanding melanogenesis and potential treatments for skin depigmentation diseases such as canities and vitiligo. Detailed protocols for McSCs regeneration, including TPA application and immunofluorescence staining to analyze melanocyte proliferation and differentiation, were provided. The findings could have implications for treating hypopigmentation in skin and hair.
Cited in this study
6 / 6 results
21 citations
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November 2017 in “Journal of Investigative Dermatology” The document concludes that understanding dermal papilla cells is key to improving hair regeneration treatments.
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September 2017 in “Oncotarget” A certain signaling pathway in mice, when increased, causes hair to gray by depleting the cells that give hair its color.
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August 2017 in “Proceedings of the National Academy of Sciences of the United States of America” Newborn mouse skin cells can grow hair and this process can be recreated in adult cells to potentially help with hair loss.
42 citations
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February 2016 in “Science” The document concludes that both internal stem cell factors and external influences like the environment and hormones affect hair loss and aging, with potential treatments focusing on these areas.
53 citations
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May 2014 in “Experimental Dermatology” Wnt10b makes hair follicles bigger, but DKK1 can reverse this effect.
260 citations
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June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
1 citations
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January 2018 in “Methods in molecular biology” The research found ways to activate melanocyte stem cells for potential treatment of skin depigmentation conditions.
36 citations
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October 2015 in “Cell reports” Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.
260 citations
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June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
