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GlossaryGray Hair (Canities)

reduced melanin production in hair follicles causes color loss

Gray hair, also known as canities, occurs when the pigment-producing cells in hair follicles, called melanocytes, decrease their production of melanin. This reduction in melanin leads to hair strands losing their color and appearing gray or white. The process is often associated with aging but can also be influenced by genetic factors, stress, and certain medical conditions.

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Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp

research Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp

14 citations, October 2020 in “Scientific reports”

Hair greying is linked to reduced ATM protein in hair cells, which protects against stress and damage.

research A Review of the Etiologies, Clinical Characteristics, and Treatment of Canities

7 citations, February 2019 in “International Journal of Dermatology”

Gray hair is caused by reduced melanin production or transfer issues, linked to aging and possibly health conditions, with treatments focusing on color camouflage.

research Canities Subita: Sudden Blanching of the Hair in History and Literature

6 citations, February 2016 in “International Journal of Dermatology”

The true cause of hair suddenly turning white is still unknown.

research Intrinsic and Extrinsic Factors Associated with Hair Graying and Therapeutic Potential of Plant Extracts and Phytochemicals

August 2024 in “Applied Sciences”

Plant extracts may help prevent or reverse hair graying.

research Demographic Characteristics and Association of Serum Vitamin B12, Ferritin, and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases

16 citations, January 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Low levels of vitamin B12 and ferritin are linked to early hair graying.

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community Why isnt topical fin talked about more?

in Chat 43 upvotes 1 week ago

Topical finasteride is less popular due to inconvenience, cost, and availability, while oral finasteride is favored for ease and safety. Some users experience side effects with topical use, but find it effective with minoxidil, though opinions on its efficacy vary.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 month ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community 1 year progress - fin only 1.25 daily

in Progress Pictures 146 upvotes 6 months ago

The conversation is about a user's one-year hair regrowth progress using 1.25mg of finasteride daily. Users are asking about the timeline of visible progress, the user's age, and whether they experienced shedding.

community The pain is real. Man bursts into tears of happiness after seeing himself with hair.

in Transplants 898 upvotes 3 years ago

Man experiences happiness after seeing himself with hair, discussing treatments like transplants, hair systems, Minoxidil, and Finasteride. Users share experiences, societal expectations, and desire for accessible solutions.