An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair

The review discusses advancements in polyurethane-related dressings for skin wound repair, emphasizing their modifiable chemical structure, biocompatibility, and multifunctional properties. These dressings, enhanced with natural and synthetic polymers and bioactive additives, show promise in improving wound healing by providing antimicrobial protection, promoting cell proliferation, and maintaining a moist environment. Innovations include the incorporation of povidone-iodine, silver nanoparticles, and bioactive compounds like LL37 peptide and exosomes, which enhance healing outcomes, particularly in complex wounds such as diabetic and infected wounds. Despite their potential, challenges like high costs, synthesis complexity, and limited commercial availability remain, necessitating further research to optimize these dressings for clinical applications.