TLDR miR-203a-3p helps hair follicle stem cells become specialized by targeting Smad1.
The study investigated the role of miR-203a-3p in promoting the differentiation of hair follicle stem cells (HFSCs) induced by loureirin A, a compound from traditional Chinese medicine. Researchers found that miR-203a-3p was upregulated in loureirin A-treated HFSCs and targeted Smad1, leading to its downregulation. This interaction promoted HFSC differentiation, suggesting miR-203a-3p as a potential molecular target for enhancing skin wound healing. The study used 180 male Sprague-Dawley rats for HFSC isolation and culture.
Cited in this study
5 / 5 results
2 citations
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November 2018 in “Cell Stem Cell” The research found a new way to heal chronic skin ulcers by turning certain cells into skin tissue using specific factors.
85 citations
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March 2018 in “Cell stem cell” Different signals work together to change gene activity and guide hair follicle stem cells to become specific cell types.
30 citations
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February 2017 in “Histochemistry and Cell Biology” TPA promotes hair growth by increasing stem cell activity and activating specific cell signals.
61 citations
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December 2016 in “The EMBO Journal” The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.
66 citations
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July 2015 in “Organogenesis” Wnt signaling is crucial for skin wound healing and reducing scars.
January 2023 in “Open Life Sciences” VEGFR-2 activation is likely involved in hair follicle growth, survival, and development.
