TLDR miR-203a-3p helps hair follicle stem cells become specialized by targeting Smad1.
The study investigated the role of miR-203a-3p in promoting the differentiation of hair follicle stem cells (HFSCs) induced by loureirin A, a compound from traditional Chinese medicine. Researchers found that miR-203a-3p was upregulated in loureirin A-treated HFSCs and targeted Smad1, leading to its downregulation. This interaction promoted HFSC differentiation, suggesting miR-203a-3p as a potential molecular target for enhancing skin wound healing. The study used 180 male Sprague-Dawley rats for HFSC isolation and culture.
129 citations,
July 2019 in “Stem Cell Research & Therapy” Epidermal stem cells help heal severe skin wounds and have potential for medical treatments.
2 citations,
November 2018 in “Cell Stem Cell” The research found a new way to heal chronic skin ulcers by turning certain cells into skin tissue using specific factors.
85 citations,
January 2018 in “Cell stem cell” Different signals work together to change gene activity and guide hair follicle stem cells to become specific cell types.
30 citations,
February 2017 in “Histochemistry and Cell Biology” TPA promotes hair growth by increasing stem cell activity and activating specific cell signals.
61 citations,
December 2016 in “The EMBO Journal” The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.
66 citations,
July 2015 in “Organogenesis” Wnt signaling is crucial for skin wound healing and reducing scars.
January 2023 in “Open Life Sciences” VEGFR-2 activation is likely involved in hair follicle growth, survival, and development.
