MiR-203a-3p Promotes Loureirin A-Induced Hair Follicle Stem Cells Differentiation by Targeting Smad1

    June 2020 in “ ˜The œanatomical record ”
    Ziwei Luo, Jianping Dou, Fangfang Xie, Jianghua Lu, Qianting Han, Xianxi Zhou, Jiechen Kong, Dongfeng Chen, Aijun Liu
    TLDR miR-203a-3p helps hair follicle stem cells become specialized by targeting Smad1.
    The study investigated the role of miR-203a-3p in promoting the differentiation of hair follicle stem cells (HFSCs) induced by loureirin A, a compound from traditional Chinese medicine. Researchers found that miR-203a-3p was upregulated in loureirin A-treated HFSCs and targeted Smad1, leading to its downregulation. This interaction promoted HFSC differentiation, suggesting miR-203a-3p as a potential molecular target for enhancing skin wound healing. The study used 180 male Sprague-Dawley rats for HFSC isolation and culture.
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