Nanoscale Microenvironment Engineering for Expanding Human Hair Follicle Stem Cells and Revealing Their Plasticity

    March 2021 in “ Journal of Nanobiotechnology ”
    Peng Chen, Feifei Zhang, Zhexiang Fan, Tianding Shen, Bingcheng Liu, Ruosi Chen, Qian Qu, Jin Wang, Yong Miao, Zhiqi Hu
    TLDR A new method was developed to grow and maintain human hair follicle stem cells for hair reconstruction.
    The study developed a novel 2D culture model using layer-by-layer (LbL) self-assembly with gelatin and alginate to create a nanoscale biomimetic extracellular matrix (ECM) for human hair follicle stem cells (HFSCs). This system aimed to expand HFSCs and reveal their plasticity by maintaining the CD200+α6+ HFSC population. The LbL coating, combined with growth factors like FGF-7, VEGF-A, and BMP2, effectively expanded and regulated HFSCs, achieving significant increases in the CD200+α6+ population. This method maintained HFSC properties without feeder cells, offering a new tool for hair follicle reconstruction and stem cell homeostasis research, with promising implications for hair regeneration therapies.
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