ROCK Inhibitor Y-27632 Maintains the Propagation and Characteristics of Hair Follicle Stem Cells

    January 2018 in “ PubMed ”
    Liyou An, Pingping Ling, Jing Cui, Jiqiang Wang, Xiumei Zhu, Jiao Liu, Yujian Dai, Yanhong Liu, Lan Yang, Fuliang Du
    TLDR Y-27632 helps hair follicle stem cells grow and keep their abilities.
    The study demonstrated that the ROCK inhibitor Y-27632 effectively maintained the propagation and stemness characteristics of hair follicle stem cells (HFSCs) derived from vibrissae and ear skin. In the presence of Y-27632, HFSCs expressed key markers (CD34, K15, ITGB1) and maintained stable ratios through multiple passages, unlike those cultured with epidermal growth factor. Upon removal of Y-27632, HFSCs differentiated into keratinocyte-like cells. Additionally, HFSCs cultured with Y-27632 formed spherical clusters, differentiated into keratinocytes and adipose cells in vitro, and regenerated hair follicles in vivo when injected into immune-deficient mice. These results suggested that Y-27632 was crucial for preserving HFSC self-renewal and differentiation potential, highlighting its importance for tissue engineering and clinical applications.
    Discuss this study in the Community →

    Research cited in this study

    16 / 16 results

    Related Community Posts Join

    6 / 573 results

      community Trying to understand finasteride side effects and post finasteride syndrome

      in Finasteride/Dutasteride  69 upvotes 5 years ago
      The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

      community Its just getting worse and worse

      in Progress Pictures  696 upvotes 2 months ago
      A 26-year-old is experiencing hair loss despite using minoxidil and dutasteride. Suggestions include shaving his head, trying oral minoxidil, or considering a hair transplant.

      community Another clueless guy fearmongering and spreading misinformation

      in Chat  251 upvotes 1 year ago
      The conversation discusses hair loss treatments, with some users advocating for finasteride and minoxidil, while others express concerns about potential side effects of finasteride. A social media influencer is criticized for promoting scalp massages and minoxidil over finasteride, which some believe is misinformation.

      community M40 - 3 Months progress on Fin/Min

      in Is this regrowth?  1399 upvotes 1 week ago
      A user reported significant hair regrowth after 3 months using 1mg oral finasteride, 1ml 5% topical minoxidil, and microneedling, along with biotin, vitamin D, iron, and zinc supplements. They are optimistic about continued progress despite initial skepticism.

      community 4600 - result 9 month - Dr. Carman

      in Progress Pictures  255 upvotes 1 year ago
      A user shared their 9-month post-hair transplant results with 4600 grafts, using only Nourkin hair vitamins, Vitamin D, and B12, and expressed satisfaction. The replies debated the necessity of medications like finasteride and minoxidil for maintaining hair health.

    Related Research

    3 / 3 results