ROCK Inhibitor Y-27632 Maintains the Propagation and Characteristics of Hair Follicle Stem Cells

    January 2018 in “ PubMed ”
    Liyou An, Pingping Ling, Jing Cui … Fuliang Du
    Studysummary This study found that the ROCK inhibitor Y-27632 maintains self-renewal and stemness of hair follicle stem cells in vitro, supporting their potential for tissue engineering applications.
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    Research cited in this study 16

    1. Hair Follicle Stem Cell Cultures Reveal Self-Organizing Plasticity of Stem Cells and Their Progeny The EMBO Journal · 2016
    2. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated With Upregulation of Cyclin D1 and Downregulation of p16 Stem Cells and Development · 2016
    3. Isolation and Characterization of Hair Follicle Stem Cells from Arbas Cashmere Goat Cytotechnology · 2016
    4. Ovine Hair Follicle Stem Cells Derived From Single Vibrissae Reconstitute Haired Skin International Journal of Molecular Sciences · 2015
    5. In Vitro Characterization of Human Hair Follicle Dermal Sheath Mesenchymal Stromal Cells and Their Potential in Enhancing Diabetic Wound Healing Cytotherapy · 2015
    6. Controllable Production of Transplantable Adult Human High-Passage Dermal Papilla Spheroids Using 3D Matrigel Culture Tissue engineering. Part A · 2014
    7. Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells Stem Cells Translational Medicine · 2014
    8. Stem Cell Dynamics in the Hair Follicle Niche Seminars in Cell & Developmental Biology · 2013
    9. Strategies to Enhance Epithelial-Mesenchymal Interactions for Human Hair Follicle Bioengineering Journal of Dermatological Science · 2013
    10. Lineage Tracing of Hair Follicle Stem Cells in Epidermal Whole Mounts Methods in molecular biology · 2013
    11. Dissecting the Bulge in Hair Regeneration Journal of Clinical Investigation · 2012
    12. Dynamic Signals for Hair Follicle Development and Regeneration Stem Cells and Development · 2011
    13. Exogenous Stimulations Change Nude Mouse Hair Cycle Pattern Journal of dermatological treatment · 2010
    14. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    15. In Vitro Differences Between Keratinocyte Stem Cells and Transit-Amplifying Cells of the Human Hair Follicle Journal of Investigative Dermatology · 2005
    16. Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003

    Related research 3

    1. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015
    2. Two- And Three-Dimensional Culture Of Keratinocyte Stem And Precursor Cells Derived From Primary Murine Epidermal Cultures Stem Cell Reviews and Reports · 2011
    3. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011