In Vitro Characterization of Human Hair Follicle Dermal Sheath Mesenchymal Stromal Cells and Their Potential in Enhancing Diabetic Wound Healing

May 2015 in “ Cytotherapy ”

Dongrui Ma, Jonah Ee Hsiang Kua, Wee Keng Lim, Seng Teik Lee, Alvin Wen Choong Chua

hair follicle dermal sheath mesenchymal stromal cells DS-MSCs bone marrow mesenchymal stromal cells BM-MSCs paracrine factors IL-6 IL-8

TLDR DS-MSCs from hair follicles may improve diabetic wound healing.

The study characterized human mesenchymal stromal cells derived from hair follicle dermal sheath (DS-MSCs) and compared them to bone marrow mesenchymal stromal cells (BM-MSCs). DS-MSCs exhibited high growth capacity, colony-forming efficiency, and the ability to differentiate into various cell types. They secreted higher levels of paracrine factors like IL-6 and IL-8, which are crucial for wound healing. The conditioned medium from DS-MSCs enhanced wound healing in vitro on human skin cells and reduced healing time in diabetic mice compared to controls. This suggested that DS-MSCs could be a promising alternative for therapeutic use in wound healing.

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