A Treatment Combination of IGF and EGF Promotes Hair Growth in the Angora Rabbit

December 2020 in “ Genes ”

Bohao Zhao, Jiali Li, Qiuran Chen, Naisu Yang, Zhiyuan Bao, Shuaishuai Hu, Yang Chen, Xinsheng Wu

insulin-like growth factor-1 epidermal growth factor hair follicle telogen anagen IGF-1 EGF HF

Studysummary This study found that a combination of insulin-like growth factor-1 and epidermal growth factor significantly promoted hair follicle growth and development in both cultured hair follicles and rabbits.

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The study found that a combination of insulin-like growth factor-1 (IGF-1) and epidermal growth factor (EGF) significantly promoted hair growth in 30 Angora rabbits. The treatment accelerated the transition from the telogen to anagen phase, increased hair shaft elongation, and enhanced hair follicle density. It also upregulated the expression of hair follicle-related genes, such as LEF1, CCND1, and WNT2, indicating a positive effect on hair follicle growth and development. These results suggested potential applications for improving hair and wool production and treating hair-related diseases in both humans and animals.

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