CircAGK Regulates High Dihydrotestosterone-Induced Apoptosis in DPCs Through the miR-3180-5p/BAX Axis

January 2023 in “ The FASEB Journal ”

Hanxiao Wei, Shuai Yang, Tian Yi, Xiaoyu Xu, Chang Liu, Caiqi Shen, Yanping Guo, Qiang Li, Peisheng Jin

CircAGK dihydrotestosterone DPCs Dermal Papilla Cells miR-3180-5p BAX apoptosis androgenetic alopecia AGA hormones DHT hair loss androgenic alopecia

TLDR CircAGK affects cell death in hair cells by controlling the miR-3180-5p/BAX pathway, which can lead to hair loss.

The study investigates the role of CircAGK in high dihydrotestosterone-induced apoptosis in DPCs (Dermal Papilla Cells) through the miR-3180-5p/BAX axis. The research found that CircAGK promotes DPC apoptosis in vitro and also promotes hair loss in AGA (Androgenetic Alopecia) mice. The study also discovered a reverse regulatory relationship between circAGK and miR-3180-5p, with miR-3180-5p inversely regulating BAX inhibition of DPC apoptosis. In the presence of hormones, CircAGK regulates DPC apoptosis through the regulation of the miR-3180-5p/BAX axis.

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19 / 19 results

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