Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting Circ_0135062/Mir-506-3p/Bax Axis

January 2024 in “ Aesthetic Plastic Surgery ”

Wuhan Wei, Guolin Zhao, Qiang Li, Jingyu Zhang, Hanxiao Wei, Caiqi Shen, Bingkun Zhao, Zhe Ji, Linna Wang, Yanping Guo, Peisheng Jin

Botulinum toxin type A androgenetic alopecia dermal papilla cells dihydrotestosterone circ_0135062 miR-506-3p Bax apoptosis Botox AGA DPCs DHT

Studysummary This study found that botulinum toxin type A inhibited apoptosis in dermal papillary cells induced by dihydrotestosterone through the circ_0135062/miR-506-3p/Bax axis.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The research investigated how Botulinum toxin type A (BTXA) can alleviate androgenetic alopecia (AGA) by inhibiting cell death in dermal papillary cells (DPCs) caused by dihydrotestosterone (DHT). The study found that BTXA prevented cell death in DPCs treated with DHT. Overexpression of circ_0135062 negated BTXA's protective effect on DHT-treated DPCs. The study also discovered that miR-506-3p interacts with Bax to inhibit cell death in DPCs by suppressing Bax expression in response to DHT damage. Additionally, circ_0135062 acted as a sponge for miR-506-3p, preventing it from targeting Bax expression. Therefore, BTXA demonstrated a protective effect against DHT-induced DPC damage through the circ_0135062/miR-506-3p/Bax axis.

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