Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting Circ_0135062/Mir-506-3p/Bax Axis

January 2024 in “ Aesthetic Plastic Surgery ”

Wuhan Wei, Guolin Zhao, Qiang Li, Jingyu Zhang, Hanxiao Wei, Caiqi Shen, Bingkun Zhao, Zhe Ji, Linna Wang, Yanping Guo, Peisheng Jin

Botulinum toxin type A androgenetic alopecia dermal papilla cells dihydrotestosterone circ_0135062 miR-506-3p Bax apoptosis Botox AGA DPCs DHT

TLDR Botox can help prevent hair loss by blocking cell death in scalp cells.

The research investigated how Botulinum toxin type A (BTXA) can alleviate androgenetic alopecia (AGA) by inhibiting cell death in dermal papillary cells (DPCs) caused by dihydrotestosterone (DHT). The study found that BTXA prevented cell death in DPCs treated with DHT. Overexpression of circ_0135062 negated BTXA's protective effect on DHT-treated DPCs. The study also discovered that miR-506-3p interacts with Bax to inhibit cell death in DPCs by suppressing Bax expression in response to DHT damage. Additionally, circ_0135062 acted as a sponge for miR-506-3p, preventing it from targeting Bax expression. Therefore, BTXA demonstrated a protective effect against DHT-induced DPC damage through the circ_0135062/miR-506-3p/Bax axis.

View this study on link.springer.com →

Discuss this study in the Community →

Cited in this study

22 / 22 results

research CircAGK Regulates High Dihydrotestosterone-Induced Apoptosis in DPCs Through the miR-3180-5p/BAX Axis

1 citations , January 2023 in “The FASEB Journal”

CircAGK affects cell death in hair cells by controlling the miR-3180-5p/BAX pathway, which can lead to hair loss.

research Construction and Functional Analysis of CeRNA Regulatory Network Related to the Development of Secondary Hair Follicles in Inner Mongolia Cashmere Goats

2 citations , August 2022 in “Frontiers in Veterinary Science”

The research found key RNA networks that may control hair growth in cashmere goats.

research Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

14 citations , March 2022 in “Journal of Biomedical Science”

Cyanidin 3-O-arabinoside may help treat a common form of hair loss by protecting cells against aging and improving cell function.

research The Potential Role of hsa_circ_0001079 in Androgenetic Alopecia via Sponging hsa-miR-136-5p

3 citations , November 2021 in “Journal of Clinical Laboratory Analysis”

research Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

12 citations , October 2021 in “Cells”

Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.

research Anti-Androgenetic Alopecia Effect of Policosanol from Chinese Wax by Regulating Abnormal Hormone Levels to Suppress Premature Hair Follicle Entry into the Regression Phase

5 citations , April 2021 in “Biomedicine & Pharmacotherapy”

Policosanol helps treat hair loss by balancing hormones and supporting hair growth.

research Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia

23 citations , January 2021 in “Biomedicine & Pharmacotherapy”

DHT stops hair regrowth in mice, similar to human hair loss.

research Hair Growth Promoting Effects of 650 nm Red Light Stimulation on Human Hair Follicles and Study of Its Mechanisms via RNA Sequencing Transcriptome Analysis

6 citations , January 2021 in “Annals of Dermatology”

650 nm red light helps hair grow and prevents hair loss by affecting certain genes and biological processes.

research Effectiveness and Safety of Botulinum Toxin Type A in the Treatment of Androgenetic Alopecia

15 citations , August 2020 in “BioMed Research International”

BTA safely and effectively treats hair loss, and works better with FNS.

research The Effect of Intradermal Botulinum Toxin on Androgenetic Alopecia and Its Possible Mechanism

15 citations , April 2020 in “Journal of The American Academy of Dermatology”

Botulinum toxin injections may help treat hair loss by blocking harmful secretion in hair follicles.

research The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

9 citations , November 2019 in “Scientific reports”

The AC 2 peptide from Trapa japonica fruit helps protect hair cells and may treat hair loss.

research Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit Hair Follicle Cycle by RNA Sequencing

35 citations , May 2019 in “Frontiers in genetics”

Non-coding RNAs play key roles in the hair growth cycle of Angora rabbits.

research Clinical Profile of Androgenic Alopecia and Its Association with Cardiovascular Risk Factors

13 citations , January 2019 in “Indian Journal of Dermatology”

research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

178 citations , July 2017 in “Journal of The American Academy of Dermatology”

Minoxidil, finasteride, and low-level laser light therapy effectively treat hair loss.

research Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia

19 citations , August 2016 in “Annals of Dermatology”

Dutasteride is safe and effective for treating hair loss, but may decrease libido.

research Ginsenoside F2 Reduces Hair Loss by Controlling Apoptosis Through the Sterol Regulatory Element-Binding Protein Cleavage Activating Protein and Transforming Growth Factor-β Pathways in a Dihydrotestosterone-Induced Mouse Model

22 citations , January 2014 in “Biological & Pharmaceutical Bulletin”

Ginsenoside F2 may help prevent hair loss and promote hair growth better than finasteride.

research Genetic Variants at 20p11 Confer Risk to Androgenetic Alopecia in the Chinese Han Population

9 citations , August 2013 in “PLOS ONE”

Genetic variants at 20p11 increase baldness risk in Chinese Han people.

research Analysis of the MicroRNA Expression Profile of Normal Human Dermal Papilla Cells Treated with 5α-Dihydrotestosterone

22 citations , March 2012 in “Molecular Medicine Reports”

DHT affects hair follicle cells by changing microRNA levels, leading to less cell growth and more cell death.